Synthesis of novel structurally simplified estrogen analogues with electron-donating groups in ring A
A library of 25 novel estrogen analogues were prepared in five to eight steps from mostly commercially available substituted anisoles via bromination, formylation, Corey-Fuchs reaction, elimination, and Sonogashira reaction. Georg Thieme Verlag Stuttgart.
Tietze, Lutz F.,Vock, Carsten A.,Krimmelbein, Ilga K.,Nacke, Linda
experimental part
p. 2040 - 2060
(2009/12/27)
The Synthesis of Hibiscoquinone C
The synthesis is reported of 7-hydroxy-5-isopropyl-3-methyl-naphthalene-1,2-dione 1 which exhibits identical spectra with tose reported for hibiscoquinone C, thus confirming the structure of the latter.The synthesis was achieved using the Stobbe condensation followed by cyclisation to obtain the naphthoate 13, reduction of the ester to a methyl group, followed by Fremy's salt oxidation and O-demethylation with boron tribromide gave 1.
Letcher, Roy M.,Lee, Chi-Fai
p. 2001 - 2015
(2007/10/03)
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