- 7,11-diaryl-2,4-diazaspiro[5.5]undecane-1,5,9-triones: A new series of spiroheterocycles
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A novel two step synthesis of 7,11-diaryl-2,4-diazaspiro[5.5]undecane-1,5,9-triones has been reported based on double Michael addition of 2-thiobarbiturates or N,N'-diaryl-2-thiobarbiturates with dibenzalacetones followed by reductive desulfurization with
- Khurana, Jitender M.,Arora, Reema,Satija, Sarishti
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p. 2709 - 2716
(2008/09/19)
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- Synthesis of 7,11-diaryl-3-oxo (or thioxo)-2,4-diazaspiro[5.5]undecane-1,5, 9-triones, Part I
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Spiro compounds 7,11-diaryl-2,4-diazaspiro[5.5]undecane-1,3,5,9-tetraones 3a-e and 7,11-diaryl-3-thioxo-2,4-diazaspiro[5.5]undecane-1,5,9-triones 3f-j were prepared from the reaction of 1,5-diaryl-1,4-pentadien-3-ones 2a-f with barbituric acid (1a) and 2-
- Ahmed, M. Giasuddin,Ahmed, Syeda Asghari,Ahmed, S. Mosaddeq,Hossain, M. Mahmun,Hussam, Abul
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p. 622 - 625
(2007/10/03)
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- Synthesis and anticonvulsant activity of some spiro compounds derived from barbituric and thiobarbituric acids: Part I
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Divinyl ketones (1), prepared by the condensation of acetone with the appropriate aromatic aldehydes, on Michael addition with barbituric and thiobarbituric acids afford the desired spiro compounds (2a-j). The ketoximes (3a-j) obtained from 2a-j on Beckmann transformation by treatment with PCl5 furnish the spiro azepines (4a-j). Alkylation of some of the compounds 2 afford the anticipated N-substituted products (5a-i). Preliminary pharmacological screening of some of the new compounds reveal their anticonvulsant activity.
- Osman,Kandeel,Said,Ahmed
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p. 1073 - 1078
(2007/10/03)
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