Synthesis and anticonvulsant activity of some spiro compounds derived from barbituric and thiobarbituric acids: Part I
Divinyl ketones (1), prepared by the condensation of acetone with the appropriate aromatic aldehydes, on Michael addition with barbituric and thiobarbituric acids afford the desired spiro compounds (2a-j). The ketoximes (3a-j) obtained from 2a-j on Beckmann transformation by treatment with PCl5 furnish the spiro azepines (4a-j). Alkylation of some of the compounds 2 afford the anticipated N-substituted products (5a-i). Preliminary pharmacological screening of some of the new compounds reveal their anticonvulsant activity.
Osman,Kandeel,Said,Ahmed
p. 1073 - 1078
(2007/10/03)
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