- PREPARATION OF METAL-PYRIDINE DERIVATIVE COMPLEXES FOR USE IN MEDICAL IMAGING
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The present invention relates to methods of forming metal-pyridine derivative complexes using pericyclic reactions with metal-1,2,4- triazine derivative complexes and a dienophile as the reactants. The reactants are bioorthogonal and the methods are parti
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Page/Page column 39; 40
(2019/07/19)
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- Deamination of 2-aminothiazoles and 3-amino-1,2,4-triazines with nitric oxide in the presence of a catalytic amount of oxygen
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2-Aminothiazoles, 2-aminobenzazoles, and 3-amino-1,2,4-triazines were deaminated using nitric oxide (NO) in the presence of a catalytic amount of oxygen to afford corresponding unsubstituted heterocycles in good yields.
- Itoh, Takashi,Matsuya, Yuji,Nagata, Kazuhiro,Ohsawa, Akio
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p. 1547 - 1549
(2007/10/03)
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- STUDIES ON as-TRIAZINE DERIVATIVES. X. ADDITION REACTION OF PHENYLMAGNESIUM BROMIDE WITH 1,2,4-TRIAZINES
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The reaction of 1,2,4-triazine with phenylmagnesium bromide was investigated.Every position 3,5, and 6 in a 1,2,4-triazine ring is active in the addition reaction of Grignard reagents.Since 5-phenyl-1,2,4-triazine, 5,6-diphenyl-1,2,4-triazine, and 3,5,6-t
- Konno, Shoetsu,Sagi, Mataichi,Yoshida, Nobuko,Yamanaka, Hiroshi
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p. 3111 - 3114
(2007/10/02)
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- Ring Transformations and Amination in Reactions of 3-Halogeno-5-phenyl-1,2,4-triazines with Potassium Amide in Liquid Ammonia
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The reactions of 3-X-5-phenyl-1,2,4-triazines (X = fluoro, chloro, bromo, iodo) toward potassium amide/liquid ammonia were studied.Whereas the 3-fluoro compound gives only the 3-amino derivative, the 3-chloro, 3-bromo, and 3-iodo compounds yield a complex mixture containing, besides 3-amino-5-phenyl-1,2,4-triazine and 5-phenyl-1,2,4-triazine, ring transformation products, i.e., 3,5-diphenyl-1,2,4-triazine, 2,4-diphenyl-1,3,5-triazine, 6-amino-2,4-diphenyl-1,3,5-triazine, and 3-X-5-phenyl-1,2,4-triazole.Evidence is found that in the ring transformation of 3-X-5-phenyl-1,2,4-triazines into 2,4-diphenyl-1,3,5-triazines, benzamidine must be an intermediate.The mechanisms of the amination and ring transformation are extensively discussed.
- Rykowski, A.,Plas, H. C. van der
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p. 881 - 885
(2007/10/02)
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