cas 181816-48-8, Ombrabulin | Articles data

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Compositions and Methods for Treatment of Cancer
Resistance of randomly dispersed and oxygen-starved lung tumor cells to chemo- and radiotherapy constitutes the vast majority recurrences and death from lung cancer. We use sickle cells derived from humans with sickle cell anemia to target oxygen-deprived
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(2020/12/17)

Prodrug Activation by a Viral Protease: Evaluating Combretastatin Peptide Hybrids to Selectively Target Infected Cells
Infections with flaviviruses such as dengue virus (DENV) are prevalent throughout tropical regions worldwide. Replication of these viruses depends on tubulin, a host cell factor that can be targeted to obtain broad-spectrum antiviral agents. Targeting of tubulin does, however, require specific measures to avoid toxic side-effects. Herein, we report the synthesis and biological evaluation of combretastatin peptide hybrids that incorporate the cleavage site of the DENV protease to allow activation of the tubulin ligand within infected cells. The prodrug candidates have no effect on tubulin polymerization in vitro and are 20-2000-fold less toxic than combretastatin A-4. Several of the prodrug candidates were cleaved by the DENV protease in vitro with similar efficiency as the natural viral substrates. Selected compounds were studied in DENV and Zika virus replication assays and had antiviral activity at subcytotoxic concentrations.
Richter, Michael,Leuthold, Mila M.,Graf, Dominik,Bartenschlager, Ralf,Klein, Christian D.
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p. 1115 - 1121
(2019/08/20)

Design, synthesis, and biological evaluation of water-soluble amino acid prodrug conjugates derived from combretastatin, dihydronaphthalene, and benzosuberene-based parent vascular disrupting agents
Targeting tumor vasculature represents an intriguing therapeutic strategy in the treatment of cancer. In an effort to discover new vascular disrupting agents with improved water solubility and potentially greater bioavailability, various amino acid prodru
Devkota, Laxman,Lin, Chen-Ming,Strecker, Tracy E.,Wang, Yifan,Tidmore, Justin K.,Chen, Zhi,Guddneppanavar, Rajsekhar,Jelinek, Christopher J.,Lopez, Ramona,Liu, Li,Hamel, Ernest,Mason, Ralph P.,Chaplin, David J.,Trawick, Mary Lynn,Pinney, Kevin G.
p. 938 - 956
(2016/02/19)

Synthesis and antitumor-evaluation of cyclopropyl-containing combretastatin analogs
Several derivatives of combretastatin have been prepared bearing a cyclopropyl unit instead of the natural occurring cis-double bond. Final products and synthetic intermediates were evaluated for their cytotoxic properties in two human cancer cell lines.
Fuerst, Rita,Zupko, Istvan,Berenyi, Agnes,Ecker, Gerhard F.,Rinner, Uwe
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p. 6948 - 6951
(2010/08/06)

Design, synthesis, and biological evaluation of combretastatin nitrogen-containing derivatives as inhibitors of tubulin assembly and vascular disrupting agents
A series of analogs with nitro or serinamide substituents at the C-2′-, C-5′-, or C-6′-position of the combretastatin A-4 (CA4) B-ring was synthesized and evaluated for cytotoxic effects against heart endothelioma cells, blood flow reduction to tumors in
Monk, Keith A.,Siles, Rogelio,Hadimani, Mallinath B.,Mugabe, Benon E.,Ackley, J. Freeland,Studerus, Scott W.,Edvardsen, Klaus,Trawick, Mary Lynn,Garner, Charles M.,Rhodes, Monte R.,Pettit, George R.,Pinney, Kevin G.
p. 3231 - 3244
(2007/10/03)

Chemical Properties

Boiling Point: 648.1 °C at 760 mmHg
Flash Point:345.8 °C
Density: 1.258 g/cm³
Storage Temp.:2-8°C
PKA: 12.03±0.10(Predicted)
PSA: 112.27000
LogP: 2.92280

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Chemical Properties

Boiling Point: 648.1 °C at 760 mmHg

Flash Point:345.8 °C

Density: 1.258 g/cm³

Storage Temp.:2-8°C

PKA: 12.03±0.10(Predicted)

PSA: 112.27000

LogP: 2.92280

Global suppliers and manufacturers of 181816-48-8total 27 suppliers on LookChem

Article Database

181816-48-8

Articles about 181816-48-8Total 5 be found

More Articles about upstream products of 181816-48-8

Chemical Properties

Boiling Point: 648.1 °C at 760 mmHg

Flash Point:345.8 °C

Density: 1.258 g/cm3

Storage Temp.:2-8°C

PKA: 12.03±0.10(Predicted)

PSA: 112.27000

LogP: 2.92280

Global suppliers and manufacturers of 181816-48-8total 27 suppliers on LookChem

Density: 1.258 g/cm³