- A Convenient Two-Step Preparation of Monodeuteriated Tetramethylsilane
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Purified partially mono-deuteriated TMS was synthesized by preparing lithiomethyltrimethylsilane from chloromethyltrimethylsilane and reaction of the former with deuteriated water.Using this reference deuterium chemical shifts in parts per million can be
- Saljoughian, Manouchehr
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- Bridging alkyls in d-transition metal chemistry: Reactions of (cod)2M2(μ-R)2 with organolithium reagents to give (cod)2M2(R)4Li2, where M is Rh or Ir, and the crystal structure of (cod)2Rh2(CH2SiMe3)4Li2 and (cod)Rh(CH2SiMe3)2Li(Me2NCH2CH2NMe2)
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The bridging alkyls, (cod)2Rh2(μ-R)2 where R is Me or Me3SiCH2, react with one molar equivalent of RLi to generate the thermally stable dialkylrhodates, (cod)Rh(R)2Li, which may be crystallized from hydrocarbons.X-ray crystallography of the compound with R=CH2SiMe3 shows that the complex is a centrosymmetric dimer with space group C2/c, a 24.370(6), b 9.946(2), c 17.791(5) Angstroem, γ 106.62(2)o, and V 4132(2) Angstroem3.The dimer is cleaved by reaction with the Lewis base, Me2NCH2CH2NMe2, to give (cod)Rh(CH2SiMe3)2Li(tmed) as shown by X-ray crystallography.The space group is Pbca, a 16.532(5), b 19.239(5), c 18.141(4), and V 5770 Angstroem3.The coordination geometry about the square planar RhI atom is similar in both compounds; RhI is bonded to cod and two CH2SiMe3 groups and the lithium atom is oriented ca. 30o off a normal to the rhodium atom towards the CH2SiMe3 groups with a Li...Rh distance of ca. 2.6 Angstroem.Solution NMR spectroscopy as a function of temperature and solvent on these and the related iridates, (cod)Ir(CH2SiMe3)2Li(tmed) and (cod)Ir(R)2Li where R is Me or CH2SiMe3, are interpreted relative to the solid state structures.
- Kulzick, Matthew A.,Andersen, Richard A.,Muetterties, Earl L.,Day, Victor W.
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- Modification of styrene polymer with organosilicon groups
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The homopolymer of 4-chloromethylstyrene (PI) and its copolymers with styrene (in various mole ratios) were synthesized by bulk and solution free radical polymerizations, respectively, at 70±1°C using α,α′-azobis(isobutyronitrile) as an initiator. Lithiat
- Assadi,Mahkam,Tajrezaiy
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- USING ALKYLMETAL REAGENTS FOR DIRECTED METALATION OF AZAAROMATICS
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Substituted alkylmetal reagents such as (trimethylsilylmethyl)lithium are reacted with azaaromatic compounds and/or nitrogen heterocycle compounds to produce functionalized azaaromatic compounds and functionalized nitrogen heterocycle compounds.
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- Cyclic dienol ethers
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The claimed invention relates to cyclic dienol ethers of formula (III). wherein R3is hydrogen and R4is C1-4alkoxy or R3and R4together form an optionally substituted methylenedioxy group —O—C(R5/
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(2008/06/13)
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- Non-steroid progesterone receptor agonist and antagonist and compounds and methods
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Non-steroidal compounds which are high affinity, high specificity ligands for progesterone receptors are disclosed. The compounds include synthetic derivatives of cyclocymopol and its diastereomers, spectroscopically and chromatographically pure (3R)-cyclocymopol monomethyl ether, which functions as a progesterone receptor antagonist, and spectroscopically and chromatographically pure (3S)-cyclocymopol monomethyl ether, which functions as a progesterone receptor agonist. Also disclosed are methods for employing the disclosed compounds for modulating processes mediated by progesterone receptors and for treating patients requiring progesterone receptor agonist or antagonist therapy.
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- Non-steroid androgen receptor antagonist compounds and methods
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Non-steroidal compounds which are high affinity, high specificity ligand antagonists for the androgen receptor are disclosed. Also disclosed are methods for employing the disclosed compounds for modulating processes mediated by the androgen receptor and for treating patients requiring androgen receptor antagonist therapy.
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