Highly enantioselective hydrogenation of itaconic acid derivatives with a chiral bisphospholane-Rh(I) catalyst
The new - commercially in multi-kg quantities available - chiral bisphospholane ligand, catA-Sium M, has been successfully used in the Rh(I)-catalysed enantioselective hydrogenation of itaconic acid derivatives. Chiral β-substituted succinic acid derivati
Almena, Juan,Monsees, Axel,Kadyrov, Renat,Riermeier, Thomas H.,Gotov, Battsengel,Holz, Jens,Boerner, Armin
p. 1263 - 1266
(2007/10/03)
Asymmetric hydrogenation of itaconic acid and enol acetate derivatives with the Rh-TangPhos catalyst
(Matrix presented) The Rh-TangPhos catalyst has been used for asymmetric hydrogenation of itaconic acid and enol acetate derivatives. A variety of chiral 2-substituted succinic acids and chiral acetates have been obtained in excellent ee values (up to 99% ee).
Tang, Wenjun,Liu, Duan,Zhang, Xumu
p. 205 - 207
(2007/10/03)
Synthetic study of AAL-toxins: Efficient construction of two vicinal diol moieties by asymmetric dihydroxylation
Asymmetric dihydroxylation has been applied to syntheses of two vicinal anti-diol moieties in key intermediates of AAL-toxins. The strategy allowed efficient construction of left- and right segments of AAL-toxin main chain.