- A large, laboratory-scale synthesis of [4-(2-(2H)-tetrahydropyranyloxy)phenyl]boronic acid
-
A large, laboratory-scale synthesis of a useful intermediate for coupling reactions, [4-(2-(2H)-tetrahydropyranyloxy)phenyl]-boronic acid, is described.
- Cladingboel, David E.
-
-
Read Online
- Cu-tethered macrocycle catalysts: Synthesis and size-selective CO2-fixation to propargylamines under ambient conditions
-
A novel air-stable, Cu-tethered macrocycle catalyst possessing a large inner cavity was successfully synthesized, creating a unique supramolecular catalytic system. The catalyst was utilized in the CO2-fixation reaction to propargylamines. The reaction proceeded more efficiently compared to the conventional CuI catalyst under atmospheric CO2 condition. Notably, owing to its topological effect, the Cu-tethered macrocycle catalyst exhibited unique substrate size selectivity.
- Kim, Nam-Kyun,Sogawa, Hiromitsu,Takata, Toshikazu
-
-
- Phosphoramidate prodrug of nucleoside analogues, a pharmaceutical composition and applications of the phosphoramidate prodrug
-
The invention relates to phosphoramidate prodrug of nucleoside analogues, or stereoisomers of the phosphoramidate prodrug, or a mixture of the stereoisomers of the phosphoramidate prodrug, or pharmaceutically acceptable salts or solvates of the phosphoramidate prodrug, and applications in the preparation of medicine for preventing or treating hepatitis B virus (HBV) and/or human immunodeficiency virus (HIV) infection alone or in combination with other medicine. The anti-HBV activity of the compound of the invention is equivalent to that of tenofovir alafenamide fumarate (TAF), and the compoundof the invention has the anti-liver fibrosis effect, can help improve the therapeutic effect of patients, and has good safety important clinical significance.
- -
-
Paragraph 0169-0171
(2019/04/10)
-
- Polymerizable compound optical element
-
PROBLEM TO BE SOLVED: To provide a polymerizable compound which has high solubility with a liquid crystal material and which has little amount of uncured monomers, high stability of a pretilt angle and hardly causes seizure when the compound is added to a liquid crystal material to manufacture a PSA (polymer sustained alignment) display element, and to provide a liquid crystal material containing the polymerizable compound.SOLUTION: The polymerizable compound is expressed by general formula (I). Further, a composition, a liquid crystal composition and an optical element including the compound are also provided.
- -
-
-
- Polymerizable compound, polymerizable composition, and liquid crystal display element
-
Provided are: a polymerizable compound having a high polymerization reactivity, a high conversion rate and a high solubility in liquid crystal compositions; a polymerizable composition containing said compound; a liquid crystal composite prepared from sai
- -
-
-
- New Dimamine compd.
-
PROBLEM TO BE SOLVED: To provide a novel diamine compound having a photoreactive group useful for production of polyamic acid, polyamic acid ester and/or polyimide contained in liquid crystal aligning agent with photo-aligning properties.SOLUTION: This in
- -
-
Paragraph 0110-0112
(2017/08/05)
-
- Recoverable fluorescence chemosensors for Ni2+ ions based on hydrogen-bonded side-chain copolymers presenting pendent benzoic acid and pyridyl receptor units
-
In this study we synthesized the novel fluorescent conjugated homopolymers P1 and P4 and the copolymers P2 and P3 containing proton-acceptor (pyridyl receptor) M1 monomer units and proton-donor (benzoic acid) M2 monomer units and investigated them as reco
- Yang, Po-Jen,Chu, Hsuan-Chih,Chen, Te-Cheng,Lin, Hong-Cheu
-
p. 12358 - 12368
(2012/10/07)
-
- A copper-based shuttling [2]rotaxane with two bidentate chelates in the axis: Steric control of the motion
-
Contrary to most of the other molecular machines based on copper-complexed catenanes or rotaxanes made and investigated in Strasbourg, the present report is dealing with a molecular shuttle for which the copper centre is complexed to two bidentate chelates, regardless of the state of the shuttle. In other words, the axis contains a sterically hindering bidentate chelate, namely a 2,9-diphenyl-1,10-phenanthroline (dpp) derivative, and another but less hindering bidentate chelate, 2,2′-bipyridine (bipy). The synthesis of the [2]rotaxane involves 15 individual chemical steps, excluding the preparation of the macrocyclic component of the [2]rotaxane. The threaded macrocycle is a 39-membered ring which incorporates an endocyclic but non sterically hindering chelate of the 8,8′-diphenyl-3,3′-biisoquinoline family (dpbiiq). The electrochemically-induced gliding motion of the copper-complexed ring from the dpp "station" to the bipy "station" and vice versa is fast on the cyclic voltammetry timescale (milliseconds). The copper(i) state is preferably located on the dpp unit whereas, by oxidising the copper(i) centre to its divalent state, the translation motion takes place to afford the thermodynamically most stable state now involving the bipy chelate.
- Collin, Jean-Paul,Durola, Fabien,Lux, Jacques,Sauvage, Jean-Pierre
-
experimental part
p. 34 - 43
(2011/01/06)
-
- A rapidly shuttling copper-complexed [2]rotaxane with three different chelating groups in its axis
-
Fast and furious: The mobile ring of a copper-complexed [2]rotaxane incorporates an endocyclic but nonsterically hindering bidentate chelate. The rotaxane axis contains three different chelates (see picture), and both terminal coordination sites are separ
- Collin, Jean-Paul,Durola, Fabien,Lux, Jacques,Sauvage, Jean-Pierre
-
supporting information; experimental part
p. 8532 - 8535
(2009/12/26)
-
- Synthesis of a bis-macrocycle containing two back-to-back rigidly connected 1,10-phenanthroline units as a central core and its incorporation in a handcuff-like catenane
-
A bis-macrocycle containing two back-to-back connected 1,10-phenanthroline chelates has been prepared. The synthetic strategy involves the preparation of a monocyclic precursor consisting of a 1,10-phenanthroline5,6-dione fragment incorporated in a 30-mem
- Frey, Julien,Kraus, Tomas,Heitz, Valerie,Sauvage, Jean-Pierre
-
p. 7584 - 7594
(2008/03/14)
-
- From terphenyl-dendronized macromonomers to aromatic-aliphatic polyethers bearing two pendant dendrons per repeating unit
-
Novel side chain dendritic aromatic-aliphatic polyethers are synthesized from aromatic terphenyl diols, disubstituted with Frechet-type dendrons of the first and second generation and aliphatic dibromides of various lengths. High-molecular-weight soluble
- Andreopoulou,Kallitsis
-
p. 5808 - 5815
(2007/10/03)
-
- Heterocyclic compounds
-
The invention concerns pharmaceutically useful compounds of the formula I, in which A1, A2, A3, A4, B1, m, Ar, W, X, Y, Z and R1 have any of the meanings defined herein, and their pharmaceutically acceptable salts, and pharmaceutical compositions containing them. The novel compounds possess endothelin receptor antagonist activity and are useful, for example, in the treatment of diseases or medical conditions in which elevated or abnormal levels of endothelin play a significant causative role. The invention further concerns processes for the manufacture of the novel compounds and the use of the compounds in medical treatment.
- -
-
-
- N-heterocyclic sulfonamides having endothelin receptor activity
-
The invention concerns pharmaceutically useful compounds of the formula I, in which R 1, R 2, R 3, n, m and Het have any of the meanings defined herein, and their pharmaceutically-acceptable salts, and pharmaceutical compositions containing them. The novel compounds possess endothelin receptor antagonist activity and are useful, for example, in the treatment of diseases or medical conditions in which elevated or abnormal levels of endothelin play a significant causative role. The invention further concerns processess for the manufacture of the novel compounds and the use of the compounds in medical treatment.
- -
-
-