The present invention relates to an improved process for preparation of highly pure benazepril of Formula I, wherein R is hydrogen or pharmacologically acceptable salt thereof by completely eliminating the impurity of 7-bromo analogue of benazepril of Formula Ia, wherein R is bromo group.
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Page/Page column 15-16
(2008/06/13)
Note on the synthesis of an optically active ACE inhibitor with amino-oxo-benzazepine-1-alkanoic-acid structure by means of an enantioconvergent crystallization-based resolution
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Boyer,Pfund r.,Portmann,Sedelmeier,Wetter
p. 337 - 343
(2007/10/02)
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