Chemoenzymic synthesis of P(α)-methyl deoxynucleoside triphosphates
5'-O-(methylphosphonyl)-N-(phenylacetyl)-2'-deoxycytidine, deoxyadenosine and deoxyguanosine were pyrophosphorylated and the resulting N-protected P(α)-methyl nucleoside triphosphates were deblocked by treatment with penicillin amidase at pH 7.8, 25°C to give P(α)-methyl nucleoside triphosphates.
Dineva, Magda A.,Petkov, Dimiter D.
p. 1459 - 1467
(2007/10/03)
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Get Best Price for182688-59-1Methyl-phosphonic acid mono-[(2R,3S,5R)-3-hydroxy-5-(2-oxo-4-phenylacetylamino-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl] ester