- COMPOUNDS AND USES THEREOF
-
The present disclosure features compounds and methods useful for the treatment of BAF complex-related disorders.
- -
-
Page/Page column 162
(2021/08/06)
-
- 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES FOR TREATING NEUROLOGICAL AND NEURODEGENERATIVE DISEASES
-
The present invention provides, in part, compounds of Formula (I): or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N- oxide, wherein: R1, R2, L, A, and E are as described herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, N-oxides, or salts, and their uses for treating M4-mediated (or M4- associated) disorders including, e.g., Alzheimer's Disease, schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.
- -
-
Page/Page column 98
(2018/02/03)
-
- PYRAZOLONE DERIVATIVE HAVING CYCLIC SIDE CHAIN
-
PROBLEM TO BE SOLVED: To provide a compound that has excellent inhibitory action on ATPase activity of TIP48/TIP49 complex and is therefore useful for the treatment of tumor, or a pharmacologically acceptable salt thereof. SOLUTION: The present invention provides a compound having a structure represented by general formula (I), its pharmacologically acceptable salt, or a pharmaceutical composition comprising the compound (where R1, R2, R3, R4, R5, R6, R7, W, and Z are as defined in the specifications). SELECTED DRAWING: None COPYRIGHT: (C)2016,JPOandINPIT
- -
-
Paragraph 0327; 0329
(2016/10/08)
-
- Synthesis and biological evaluation of 3-phenethylazetidine derivatives as triple reuptake inhibitors
-
We report the synthesis of 3-phenethylazetidine derivatives 2 and their biological activities against 5-HT, NE and DA transporters as well as microsomal stability, CYP inhibition, and hERG inhibition profiles. Compound 2at showed most potent triple reupta
- Yun, Jun,Han, Minsoo,Song, Chiman,Cheon, Seung Hoon,Choi, Kihang,Hahn, Hoh-Gyu
-
supporting information
p. 3234 - 3237
(2014/07/22)
-
- A Straightforward Synthesis of Azetidin-3-ylacetic Acid
-
The preparation of azetidin-3-ylacetic acid from epichlorohydrin via diethyl 2-[1-(diphenylmethyl)azetidin-3-yl] propane-1,3-dioate is described.
- Carruthers, Nicholas I.,Wong, Shing-Chun,Chan, Tze-Ming
-
p. 430 - 431
(2007/10/03)
-