- TRICYCLIC HETEROAROMATIC COMPOUNDS AS ALPHA-SYNUCLEIN LIGANDS
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Derivatives of phenothiazine, phenoxazine, and phenazine compounds and their use as α-synuclein ligands are described. Also described are methods of using these compounds and their radiolabeled analogs for the detection, monitoring, and treatment of synucleinopathies, including Parkinson's disease.
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- Photochemical Reductive Acylation and Oxidative Acyl Activation on Phenazine and Related Nitrogen Heterocycles
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Irradiation of phenazine in acetaldehyde or propionaldehyde solution gave an N-acylated 5,10-dihydrophenazine.Acridine similarly gave 9-acyl-9,10-dihydroacridine, and 10-methylacridinium salt gave 9-acyl-10-methyl-9,10-dihydroacridine.In methanol N-acylated dihydrophenazines reacted with N-bromosuccinimide to give phenazine and methyl carboxylates in quantitative yield.
- Takagi, Makoto,Goto, Setsuo,Matsuda, Tsutomu
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p. 1777 - 1778
(2007/10/02)
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