- Monoamine transporter binding, locomotor activity, and drug discrimination properties of 3-(4-substituted-phenyl)tropane-2-carboxylic acid methyl ester isomers
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The monoamine transporter binding properties, gross behavior, and locomotor activity effects in mice and drug discrimination results in cocaine-trained rats of the 2β,3β-, 2β,3α-, 2α,3β-, and 2α,3α-isomers of several 3-(4-substituted-phenyl)tropane carbox
- Carroll, F. Ivy,Runyon, Scott P.,Abraham, Philip,Navarro, Hernan,Kuhar, Michael J.,Pollard, Gerald T.,Howard, James L.
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- Synthesis and biological evaluation of 2β,3α-(substituted phenyl)nortropanes as potential norepinephrine transporter imaging agents
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A series of 2β,3α-(substituted phenyl)nortropanes was synthesized and evaluated in vitro for human monoamine transporters. All compounds studied in this series exhibited nanomolar potency for the norepinephrine transporter (NET). Radiolabeling and nonhuma
- Zeng, Fanxing,Stehouwer, Jeffrey S.,Jarkas, Nachwa,Voll, Ronald J.,Williams, Larry,Camp, Vernon M.,Votaw, John R.,Owens, Michael J.,Kilts, Clinton D.,Nemeroff, Charles B.,Goodman, Mark M.
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p. 3044 - 3047
(2008/02/05)
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- Dopamine transporter imaging ligand
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The 3α isomer of RTI-55, RTI-352, is an effective in vivo binding ligand that reflects greater selectivity for the dopamine transporter than is observed with RTI-55. In addition, there is also a more rapid achievement of apparent equilibrium in the striat
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(2010/01/30)
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- Synthesis and binding affinities of 2β-(3-iodoallyloxycarbonyl)-3β-(4-substituted-aryl)tropane analogues as ligands for the dopamine transporter studies
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Tropane analogues from cocaine, which is known to be one of the most reinforcing and addictive compounds, were designed, synthesized, and characterized for inhibition of presynaptic uptake of dopamine (DA) in brain. Eight new derivatives of 3β-aryl-2β-(3-iodoallyloxycarbonyl)tropanes were synthesized and tested for their potential abilities to displace [3H]2β-carbomethoxy-3β-(4-fluorophenyl)tropane (WIN 35,428) binding to the rat striatal membranes.
- Chung, Kyoo-Hyun,Lim, Choong Hwan,Lee, Dong Reyoul,Jin, Changbae,Chi, Dae Yoon
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p. 3077 - 3080
(2007/10/03)
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