Palladium-Catalyzed C8-Oxygenation of Naphthalene Derivatives: Direct Access to Naphtholactone Skeleton
Herein, a direct C8-oxygenation of naphthalene derivatives is described. Different carbonyl groups were used as directing group to deliver corresponding naphthols via a palladium-catalyzed oxidation reaction using PhI(OAc)2 in a TFA/TFAA mixture. Interestingly, when Weinreb amide was employed as the directing group, the naphtholactone skeleton was directly obtained. This methodology was applied to the synthesis of variously substituted naphtholactones. (Figure presented.).
Berrou, Caroline,Prévost, Sébastien
supporting information
p. 4091 - 4095
(2021/07/19)
Novel chromogenic aminopeptidase substrates for the detection and identification of clinically important microorganisms
A series of amino acid derivatives 8-10, 42 and 43 have been prepared as chromogenic enzyme substrates in order to detect aminopeptidase activity in clinically important Gram-negative and Gram-positive bacteria. Enzymatic hydrolysis liberates the amino ac
Cellier, Marie,James, Arthur L.,Orenga, Sylvain,Perry, John D.,Rasul, Ari K.,Robinson, Shaun N.,Stanforth, Stephen P.
p. 5249 - 5269
(2014/12/11)
Ruthenium(II)-catalyzed synthesis of hydroxylated arenes with ester as an effective directing group
An unprecedented Ru(II) catalyzed ortho-hydroxylation has been developed for the facile synthesis of a variety of multifunctionalized arenes from easily accessible ethyl benzoates with ester as an efficient directing group. Both the TFA/TFAA cosolvent system and oxidants serve as the critical success factors in this transformation. The reaction demonstrates excellent reactivity, good functional group tolerance, and high yields.
Yang, Yiqing,Lin, Yun,Rao, Yu
supporting information; experimental part
p. 2874 - 2877
(2012/07/28)
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