cas 18501-20-7, 1-hydrazino-2-propanol(SALTDATA: FREE) | Articles data ｜lookchem

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18501-20-7

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Potekhin,A.A.,Zaitsev,B.D.
(1971)
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Design, synthesis and biological evaluation of new pyrazolyl-ureas and imidazopyrazolecarboxamides able to interfere with MAPK and PI3K upstream signaling involved in the angiogenesis
Taking into account the structure activity relationship information given by our previous studies, we designed and synthesized a small library of pyrazolylureas and imidazopyrazolecarboxamides fluorinated on urea moiety and differently decorated on pyrazo
Meta, Elda,Brullo, Chiara,Sidibe, Adama,Imhof, Beat A.,Bruno, Olga
p. 24 - 35
(2017/04/06)

1-Methyl and 1-(2-hydroxyalkyl)-5-(3-alkyl/cycloalkyl/phenyl/naphthylureido)-1H-pyrazole-4-carboxylic acid ethyl esters as potent human neutrophil chemotaxis inhibitors
In this paper we report the synthesis and the chemotaxis inhibitory activity of a number of 1H-pyrazole-4-carboxylic acid ethyl esters 2 functionalized in N1 with a methyl group or different hydroxyalkyl chains and in position 5 with a series of 3-substituted urea groups. These compounds were designed as development of previous pyrazole-urea derivatives that resulted potent IL8-induced neutrophil chemotaxis inhibitors in vitro. Most of the new compounds revealed a potent inhibition of both IL8- and fMLP-OMe-stimulated neutrophil chemotaxis. The most active compounds in the fMLP-OMe induced chemotaxis test showed IC50 in the range 0.19 nM-2 μM; but we observed a very strong inhibition in the IL8-induced chemotaxis test, having the most active compounds IC50 at pM concentrations. In vivo compounds 2e and 2f, although to a lesser extent, at 50 mg/kg os decreased granulocyte infiltration in zymosan-induced peritonitis in mice.
Bruno, Olga,Brullo, Chiara,Bondavalli, Francesco,Schenone, Silvia,Spisani, Susanna,Falzarano, Maria Sofia,Varani, Katia,Barocelli, Elisabetta,Ballabeni, Vigilio,Giorgio, Carmine,Tognolini, Massimiliano
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p. 3379 - 3387
(2009/09/27)

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Chemical Properties

Boiling Point: 244.9 °C at 760 mmHg
Flash Point:101.9 °C
Density: 1.019 g/cm³
Vapor Pressure: 0.00495mmHg at 25°C
Refractive Index: 1.467
PKA: 14.86±0.20(Predicted)
PSA: 58.28000
LogP: -0.07830

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