Direct access to α-sulfenylated amides/esters: Via sequential oxidative sulfenylation and C-C bond cleavage of 3-oxobutyric amides/esters
An efficient, environmentally benign and unprecedented synthesis of various α-sulfenylated amides/esters has been developed under oxygen atmosphere. The reaction shows good functional group tolerance and excellent chemo/regioselectivity. All the desired products were obtained in moderate to excellent yields, even on the gram scale. Practically, the related α-thiol Weinreb amide can be readily transferred to a series of prospective compounds, and selenium atom can be introduced to the α-sites of the amides in high yields.
Asymmetric cyclopropanation of alkenes and diazocarbonyl insertion into S-H bonds catalyzed by a chiral porphyrin Ru(II) complex
A homochiral porphyrin ruthenium(II) complex catalyzes the cyclopropanation of styrene derivatives with ethyl diazoacetate with good yields and moderate enantiomeric excesses (46-52%). The catalyst is also active for diazocarbonyl compound insertion into S-H bonds, but with low ee.
Differential eudismic ratios in the antagonism of human platelet function by phenoxy- and thiophenoxyacetic acids
The antilipidemic drug clofibric acid (CPIB) exhibits antiplatelet effects. In order to examine the role of enantioselectivity and hydrophobicity, the mono(desmethyl) enantiomers of 2-(4-chlorophenoxy)propanoic acid (CPPA), related butanoate homologs, 2-(
Romstedt,Lei,Feller,Witiak,Loiodice,Tortorella
p. 107 - 114
(2007/10/03)
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