cas 187085-97-8, (RS)-1-[3,5-BIS(TRIFLUOROMETHYL)PHENYL]ETHYLAMINE | Articles data ｜lookchem

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187085-97-8

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GAMMA-AMINOAMIDE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY
The present invention is directed to compounds of the formula (I), wherein R1, R2, R3, R4, R5, R6, R7, R8, R11, R12, W, X, and n are defined herein, which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.
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Page/Page column 155

(2010/02/07)

Cyclohexyl derivatives and their use as therapeutic agents
The present invention relates compounds of the formula (I): wherein ring A is a phenyl or pyridyl ring; X represents a linker selected from the group consisting of: (a), (b), (c), (d), (e), (f), (g), (h), (i), (j), (k), (l) and R1, R2, R3, R4, R5, R6, R7, R13, R14, R15, R16, R?17, R18, R19, R21a and R21b are as defined herein. The compounds are of particular use in the treatment or prevention of depression, anxiety, pain, inflammation, migraine, emesis or postherpetic neuralgia.
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Page 21

(2010/02/03)

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Chemical Properties

Boiling Point: 168.9°Cat760mmHg
Flash Point:66.3°C
Density: 1.327g/cm³
PSA: 26.02000
LogP: 4.44420

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