- A generalized solvent basicity scale: The solvatochromism of 5-nitroindoline and its homomorph 1-methyl-5-nitroindoline
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A total of 202 organic solvents and the gas phase were placed on a solvent basicity scale for hydrogen bond acceptor based on parameter SB. The value of such a parameter can readily be determined from the UV/Vis spectrum for an appropriate acid probe (5-nitroindoline) (NI) and its non-acid homomorph (1-methyl-5-nitroindoline) (MNI). The proposed scale can advantageously substitute the more widely used solvent scales such as Gutmann's donor number (DN), the Koppel-Palm B(MeOD) scale, and the Taft-Kamlet β scale. While data for the proposed scale are derived only from electronic transitions, they are accurately descriptive of solvent basicity in both spectroscopy (UV/Vis, IR and NMR) and miscellaneous chemical areas (thermodynamic, kinetics, and electrochemistry). VCH Verlagsgesellschaft mbH, 1996.
- Catalan, Javier,Diaz, Cristina,Lopez, Vicenta,Perez, Pilar,De Paz, Jose-Luis G.,Rodriguez, Jose Gonzalo
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Read Online
- HEAT SHOCK PROTEIN 90 INHIBITORS
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Substituted aromatic compounds of formula (I) shown below: (formula I) The definition of each variable in formula (I) appears in the Specification. Also disclosed is a pharmaceutical composition containing one of the substituted aromatic compounds. Further disclosed is a method of using one of these compounds for treating a medical condition associated with HSP90.
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Page/Page column 23; 33; 35
(2018/10/19)
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- IMIDAZOPYRIDINES AS A NOVEL SCAFFOLD FOR MULTI-TARGETED KINASE INHIBITION
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Compounds that inhibit protein kinases, compositions containing the compounds and methods of treating diseases using the compounds are disclosed. Formula (I).
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Page/Page column 211
(2011/05/11)
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- ANTIFUNGAL AGENTS
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Compounds of formula (I), and pharmaceutically acceptable salts thereof, may be used in therapy, for example as antifungal agents: (I) wherein: Rl, R2, R3, R4, R5, R6, R7, X and X1 are as defined herein. Certain compounds of formula (I) are also provided. Compounds of formula (T), and agriculturally acceptable salts thereof, may also be used as agricultural fungicides.
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Page/Page column 48; 50
(2008/06/13)
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- Vanilloid receptor ligands and their use in treatments
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Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.
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- Amidine derivatives, their preparation and application as medicines and pharmaceutical compositions containing same
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Amidine compounds of the formula wherein the substituents are defined as in the application useful as NO-synthase enzyme inhibitors.
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Page/Page column 55
(2008/06/13)
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