- Method for preparing 2-(6-trifluoromethylpyridine-2-yloxymethyl) methyl phenylacetate
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The invention provides a method for preparing methyl 2-(6-trifluoromethylpyridine-2-yloxymethyl) phenylacetate, and belongs to the technical field of preparation of pesticide intermediates. The preparation method comprises the following steps: by taking 3
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Paragraph 0067; 0069; 0071-0073; 0075-0076; 0078
(2021/04/28)
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- Novel process for synthesizing cyproconazole intermediate alpha ketone
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The invention relates to a novel process for synthesizing cyproconazole intermediate alpha ketone, which comprises the steps of reacting a metered potassium hydroxide aqueous solution with 2-fluorine-5-trifluoromethylpyridine, neutralizing with sulfuric acid, filtering, washing, drying to obtain trifluoropyridinol, and reacting DMF, trifluoropyridinol, methyl o-chloromethylphenylacetate and sodiumhydroxide to obtain ether ester; then reacting toluene, ether ester, methyl formate and sodium hydroxide for desolvation to obtain enol; and finally reacting dichloromethane, enol, dimethyl sulfate and sodium hydroxide, filtering and drying to obtain a finished picoxystrobin product, so that the whole reaction condition is mild, the operation is simple, the method is a relatively ideal industrialsynthesis route, the total synthesis yield reaches 65% or above, and the product content reaches 97%.
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Paragraph 0019
(2020/12/15)
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- NOVEL CRYSTALLINE FORM OF PICOXYSTROBIN, METHOD OF PREPARING AND USE OF THE SAME
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A novel crystalline form of the compound of formula (I) (picoxystrobin) is provided. The novel crystalline form of picoxystrobin may be prepared by crystallization from solution in a suitable solvent. Fungicidal compositions comprising the novel crystalline form, a method for controlling fungal infestations at a locus and a use of the novel crystalline form are also provided.
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Page/Page column 13
(2017/09/28)
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- Process for the preparation of 2-(6-substituted pyrid-2-yloxymethyl) phenylacetate
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PCT No. PCT/GB96/01311 Sec. 371 Date Dec. 2, 1997 Sec. 102(e) Date Dec. 2, 1997 PCT Filed Jun. 3, 1996 PCT Pub. No. WO97/01538 PCT Pub. Date Jan. 16, 1997A process for preparing 2-(6-substituted pyrid-2-yloxymethyl)phenyacetates especially useful as intermediates for producing agricultural fungicides. The invention provides a compound having the formula (I): wherein A and D are independently selected from the group comprising halo, hydroxy, halo(C1-4)alkyl, C1-4alkoxy, thio(C1-4)alkoxy, halo(C1-4)alkoxy, phenyl, phenoxy, nitro, amino, aclyamino, cyano, carboxy, C1-4 alkoxycarbonyl and C1-4 alkylcarbonyloxy, or D is C1-4 alkyl, and m is 0 or an integer of from 1 to 3. The process comprises treating a compound of formula (II): wherein A, D and m are defined as above and M is a metal atom, with a compound of formula (III): wherein L is a leaving group.
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