- Novel small molecule inhibitors targeting the "switch region" of bacterial RNAP: Structure-based optimization of a virtual screening hit
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Rising resistance against current antibiotics necessitates the development of antibacterial agents with alternative targets. The "switch region" of RNA polymerase (RNAP), addressed by the myxopyronins, could be such a novel target site. Based on a hit can
- Sahner, J. Henning,Groh, Matthias,Negri, Matthias,Haupenthal, J?rg,Hartmann, Rolf W.
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p. 223 - 231
(2013/10/01)
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- Synthesis of novel 2-thienylimino-1,3-thiazolidin-4-ones
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The preparation of new 2-thienylimino-1,3-thiazolidin-4-ones from 3-aminothiophene-2-carboxylate using an easy four-step procedure is described. Georg Thieme Verlag Stuttgart New York.
- Abdillahi, Ismail,Revelant, Germain,Datoussaid, Yazid,Kirsch, Gilbert
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experimental part
p. 2543 - 2546
(2010/09/08)
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- THERAPEUTIC AGENTS
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Compounds of formula (I), processes for preparing such compounds, their use in the treatment of obesity, psychiatric disorders, cognitive disorders, memory disorders, schizophrenia, epilepsy, and related conditions, and neurological disorders such as dementia, multiple sclerosis, Parkinson's disease, Huntington's chorea and Alzheimer's disease and pain related disorders and to pharmaceutical compositions containing them.
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Page/Page column 22-23
(2010/11/25)
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- THERAPEUTIC AGENTS
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Compounds of formula (I), processes for preparing such compounds, their use in the treatment of obesity, psychiatric disorders, cognitive disorders, memory disorders, schizophrenia, epilepsy, and related conditions, and neurological disorders such as deme
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Page/Page column 19
(2010/11/25)
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- THERAPEUTIC AGENTS
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Compounds of formula (I), processes for preparing such compounds, their use in the treatment of obesity, psychiatric disorders, cognitive disorders, memory disorders, schizophrenia, epilepsy, and related conditions, and neurological disorders such as deme
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Page/Page column 20
(2010/11/25)
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- SUBSTITUTED HETEROCYCLES AND THE USES THEREOF
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This invention relates to novel compounds having the structural formula (I) and to their pharmaceutical compositions and to their methods of use. These novel compounds provide a treatment or prophylaxis of cancer.
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Page/Page column 109
(2010/02/12)
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