- Novel pseudo[2]rotaxanes constructed by the self-assembly of dibenzyl tetramethylene bis-carbamate derivatives and per-ethylated pillar[5]arene
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Novel neutral guest molecules, G1-G7, are studied for their host-guest complexation with per-ethylated pillar[5]arene (EtP[5]A). Among them, G1 and G7, dibenzyl tetramethylene bis-carbamate derivatives, are found to afford a novel stable pseudo[2]rotaxane
- Xiong, Shuhan,Zhang, Xiaoning,Meng, Lu-Bo,Jiang, Juli,Lin, Chen,Wang, Leyong
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- Syntheses of [13C,15N]-Labeled Polyamines
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[1,4-13C2, 1,4-15N2]butanediamine (1), a key compound in the syntheses of [5,8-13C2, 1,4,8-15N3]spermidine (2) and [5,8-13C2, 1,4,8,12-15N4]spermine (3), has been prepared as part of a 6-step process from 1,2-dibromoethane using potassium [13C]cyanide and potassium [15N]phthalimide. In the course of the syntheses, it was found that 1,4-dibromobutane was generated from tetrahydrofuran when bromination using triphenylphosphine and tetrabromomethane took place. A high-yield preparation of monobenzyloxycarbonyl (Z) derivative of 1, a precursor for 2, was obtained using a water-soluble Z reagent, Z-DSP, in a two-phase system of alkaline solution and chloroform. All the steps for 1, 2, and 3, were aimed at minimizing the loss of stable isotopes.
- Hara, Takeshi,Xu, Yong Ji,Sasaki, Hitomi,Niitu, Masaru,Samejima, Keijiro
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p. 1005 - 1012
(2007/10/03)
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- Practical, convergent total synthesis of polyamine amide spider toxin NSTX-3
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A practical, total synthesis of polyamine amide spider toxin NSTX-3, a potent glutamate receptor antagonist with potential as a neuroprotective agent, is reported. The unsymmetrical polyamine moiety was built by a conjugate addition to afford putreanine and regioselective acylation of L-asparaginyl-cadaverine.
- Blagbrough, Ian S.,Moya, Eduardo,Walford, Steven P.
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p. 551 - 554
(2007/10/02)
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- SYNTHESIS OF N-(1-URACILYLALKYL)POLYMETHYLENEDIAMINES
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The alkylation of polymethylenediamines with 2-(1-uracilyl)ethyl bromide and 3-(1-uracilyl)propyl bromide yields the corresponding N-(1-uracilylalkyl)polymethylendiamines.
- Lulle, I. Zh.,Kagan, T. I.,Paegle, R. A.,Lidak, M. Yu.
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p. 1224 - 1227
(2007/10/02)
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