- A practical synthesis of ATB-[2-3H]BMPA, a photolabelling reagent for exofacial glucose transporters
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Major improvements in the efficiency of ATB-[2-3H]BMPA synthesis were achieved by using 1,3-dichloro-2-propanone O-benzyloxime (6) as the linking reagent.
- Sher, Philip M.,Kronenthal, David R.
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- Synthetic studies towards 4,10-diaza-1,7-dioxaspiro[5.5]undecanes: access to 3-aza-6,8-dioxabicyclo[3.2.1]octan-2-one and 2H-1,4-oxazin-3(4H)-one frameworks
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Synthetic approaches towards 4,10-diaza-1,7-dioxaspiro[5.5]undecanes starting from 1,3-dichloroacetone and solketal derivatives are explored. The method relies on the preparation of a key bis-substituted dihydroxy-protected oxime, which would undergo a final acidic deprotection-spiroacetalization process. Although the desired diazaspiroketal framework could not be obtained, our conditions led to the unexpected 3-aza-6,8-dioxabicyclo[3.2.1]octan-2-one 18 or to the oxazinone 32 in good yields.
- Goubert, Marlène,Toupet, Lo?c,Sinibaldi, Marie-Eve,Canet, Isabelle
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p. 8255 - 8266
(2008/02/08)
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