TAK-599, a novel N-phosphono type prodrug of anti-MRSA cephalosporin T-91825: Synthesis, physicochemical and pharmacological properties
Crystalline 1 (TAK-599) is a novel N-phosphono prodrug of anti-methicillin-resistant Staphylococcus aureus (MRSA) cephalosporin 2a (T-91825) that has high affinity for penicillin-binding protein (PBP) 2′ (IC50; 0.90 μg/mL) and shows potent in v
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8-oxo-7-[(phenylacetyl)amino]-3-[[4-(4-pyridinyl)-2-thiazolyl]thio]-,
(4-methoxyphenyl)methyl ester, (6R,7R)-