- Complete post-synthetic modification of a spin crossover complex
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The post-synthetic reaction between p-anisaldehyde and the spin-crossover compound [Fe(NH2-trz)3](NO3)2 was explored, obtaining different degrees of transformation from 23% to full conversion by varying the reaction time. The post-synthetic SCO complexes obtained were studied by magnetometry, powder X-ray diffraction (PXRD), elemental analysis, solid state NMR and IR and compared with the corresponding compounds obtained by direct synthetic routes, revealing new spin crossover properties.
- Enríquez-Cabrera, Alejandro,Routaboul, Lucie,Salmon, Lionel,Bousseksou, Azzedine
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- Complete and Versatile Post-Synthetic Modification on Iron-Triazole Spin Crossover Complexes: A Relevant Material Elaboration Method
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In this paper we study the post-synthetic modification (PSM) reaction on solid spin crossover (SCO) [Fe(NH2trz)3]X2 (X=NO3, OTs, Cl, SO4, BF4) complexes with different substrates. The wide access to a diversity of functionalized complexes with imine, amide and carbamide groups from the same amino parent compound demonstrates the synthetic approach value of this method. The as-obtained post-synthetic complexes were studied by IR, solid NMR, elemental analyses, and powder X-ray diffraction, and compared to the corresponding compounds obtained by direct synthesis (DS) routes. Moreover, after digestion of the complexes obtained by PSM reactions, the free ligands were characterized by NMR in solution, which allowed us to indirectly confirm the formation of complexes we wished to synthesize. The study reveals in numerous cases that a complete post-synthetic modification is possible despite the structural cohesion that is established between the 1D coordination chains within these materials. Spin crossover properties of some complexes obtained by both methods are also reported and compared.
- Enríquez-Cabrera, Alejandro,Ridier, Karl,Salmon, Lionel,Routaboul, Lucie,Bousseksou, Azzedine
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supporting information
p. 2000 - 2016
(2021/05/17)
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- Antiglycation activity of triazole schiff’s bases against fructose-mediated glycation: In vitro and in silico study
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Background: Advanced glycation end products (AGEs) are known to be involved in the pathophysiology of diabetic complications, neurodegenerative diseases, and aging. Preventing the formation of AGEs can be helpful in the management of these diseases. Objec
- Choudhary, Muhammad I.,Imad, Rehan,Khan, Khalid M.,Naqeeb, Uzma,Shaikh, Muniza,Siddiqui, Salman,Subzwari, Fakiha,Zafar, Humaira
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p. 575 - 591
(2020/06/21)
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- An Efficient Synthesis and Antibacterial Activity of Some Novel 2-Azetidinone Derivatives of 4H-1,2,4-Triazoles Under Mild Conditions
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We have synthesized the novel 2-azetidinone derivatives by using Schiff bases of 1,2,4-triazoles via a single step protocol. We used DABCO as a good homogenous, ecofriendly, highly reactive, easy to handle, and nontoxic catalyst. In?DABCO catalyzed synthesis of active 2-oxo-azetidine, a highly electrophilic ketene intermediate can react with weakly nucleophilic (N═CH) linkage, which is used as the precursor for the cycloaddition reaction to deliver the desired products in excellent yields with protic solvents. In addition, the DABCO as an economically viable and readily available catalyst is soluble in almost all solvents and their salts easily filtered off from the reaction medium. Moreover, this new synthetic protocol features high conversion in green solvents and a straightforward procedure.
- Khan, Takallum,Yadav, Ritu,Gound, Surendra Singh
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supporting information
p. 1042 - 1047
(2018/02/23)
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- Synthesis and biological screening of some new thiophene and pyrazole containing styrylchromones and pyrazoles
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Series of brominated thiophene anchored 2-styrylchromones and styrylpyrazoles were synthesized using Baker-Venkataraman transformation. The structures of newly synthesized compounds were confirmed by spectral techniques such as infrared, 1H nuc
- Mhaske, Sadhana D.,Takate, Sushama J.,Dhawale, Rhushikesh N.,Akolkar, Hemantkumar N.,Randhavane, Pratibha V.,Karale, Bhausaheb K.
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- Synthesis of triazole Schiff bases: Novel inhibitors of nucleotide pyrophosphatase/phosphodiesterase-1
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A series of Schiff base triazoles 1-25 was synthesized and evaluated for their nucleotide pyrophosphatase/phosphodiesterase-1 inhibitory activities. Among twenty-five compounds, three compounds 10 (IC50 = 132.20 ± 2.89 μM), 13 (IC50
- Khan, Khalid Mohammed,Siddiqui, Salman,Saleem, Muhammad,Taha, Muhammad,Saad, Syed Muhammad,Perveen, Shahnaz,Choudhary, M. Iqbal
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supporting information
p. 6509 - 6514
(2015/02/19)
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- Push-pull triazenes derived from 1-(benzylideneamino)- and 1-(sulfonimido)-azolylidenes
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In-situ-generated neutral 1-(benzylideneamino)- and novel anionic 1-(sulfonimido)-azolylidenes react with organic azides to afford diverse classes of push-pull triazenes and triazene salts. The scope of the heterocyclic core and substituents at the N1 and
- Jishkariani, Davit,Dennis Hall,Demircan, Aydin,Tomlin, Blake J.,Steel, Peter J.,Katritzky, Alan R.
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p. 3349 - 3354
(2013/06/27)
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- Triazole and benzotriazole derivatives as novel inhibitors for p90 ribosomal S6 protein kinase 2: Synthesis, molecular docking and SAR analysis
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A series of triazole and benzotriazole derivatives as novel p90 ribosomal S6 protein kinase 2 (RSK2) inhibitors were designed and synthesized. The in vitro activities against RSK2 were evaluated, and among 14 compounds, compounds 5, 6, 11, 12, 13 and 14 exhibited enzyme IC50 values of 8.91, 2.86, 3.19, 3.05, 4.49 and 2.09 μmol/L respectively. The proposed binding modes were simulated using molecular docking method, and the docking results coupled with the structure-activity relationship (SAR) analysis indicated that all these active compounds bound to the RSK2 ATP binding site at NTKD, and the electron-donating groups on the 4-position of phenyl were the determinant point for the inhibitory activity. In the present study, a series of triazole and benzotriazole derivatives as novel p90 ribosomal S6 protein kinase 2 (RSK2) inhibitors were designed and synthesized. The in vitro activities of the 14 compounds against RSK2 were evaluated, among which, compounds 5, 6, 11, 12, 13 and 14 exhibited enzyme IC50 values of 8.91, 2.86, 3.19, 3.05, 4.49 and 2.09 μmol/L respectively. The proposed binding modes were simulated using molecular docking method, and the docking results coupled with the structure-activity relationship (SAR) analysis indicated that all our active compounds bound to the RSK2 ATP binding site at NTKD, and the electron-donating groups on the 4-position of phenyl were the key point for the inhibitory activity. Copyright
- Yuan, Jun,Zhong, Ye,Li, Shiliang,Zhao, Xue,Luan, Guoqin,Zhao, Zhenjiang,Huang, Jin,Li, Honglin,Xu, Yufang
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p. 1192 - 1198
(2013/10/21)
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- Synthesis and biological activity of 3-[4H-(1,2,4)-Triazolyl]-2,6-diaryl-1, 3,5-oxadiazine-4-thione
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4-Amino-1,2,4-triazole (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding 4-(arylidene-amino)-4H-[1,2,4]-triazole (2a-h) in good yield. Rearrangement of compounds (2a-h) with benzoyl isothiocyanate/4-chloro-benzoyl isoth
- Patel, Hasmukh S.,Patel, Ketan B.
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experimental part
p. 2443 - 2452
(2010/07/04)
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- Synthesis and biological activity of 3-[4H-(1,2,4)-triazolyl]-2-aryl-1,3- thiazolidin-4-ones
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4-Amino-1,2,4-triazole (1) undergoes facile condensation with aromatic aldehydes to afford the corresponding 4-(arylidene-amino)-4H-[1,2,4]-triazole (2 a-h) in good yields. Cyclocondensation of compounds (2 a-h) with thioglycolic acid yields 3-[4H-(1,2,4)
- Patel,Patel
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experimental part
p. 2391 - 2398
(2009/08/07)
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