Synthesis of silicon analogues of acyclonucleotides incorporable in oligonucleotide solid-phase synthesis
The synthesis of the four silicon analogues of acyclonucleosides was described. In every case, the silicon atom was introduced onto an allyl group on the natural nucleobase following a hydrosilylation reaction. Diols obtained were protected as 4,4'-dimethoxytrityl ethers and subsequently activated as 2-cyanoethyl N,N-diisopropylchlorophosphoramidite in order to be suitable for oligonucleotide solid phase synthesis.
Thibon, Jacques,Latxague, Laurent,Deleris, Gerard
p. 4635 - 4642
(2007/10/03)
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