Novel glucocorticoid antedrugs possessing a 21-(γ-lactone) ring
Pregnane derivatives bearing γ-butyrolactones at C21 were prepared and tested as glucocorticoid agonists. The compounds were also tested for their liability in human plasmas. The compounds were found to be rapidly hydrolyzed by the enzyme paraoxonase to the respective hydroxyacids.
Angell, Richard M.,Biggadike, Keith,Farrell, Rosanne M.,Flack, Stephen S.,Hancock, Ashley P.,Irving, Wendy R.,Lynn, Sean M.,Procopiou, Panayiotis A.
p. 831 - 839
(2007/10/03)
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