- PHOTOLABILE DINITROINDOLINYL BASED COMPOUNDS
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The present invention relates to photolabile or photoreleasable compounds including a caging moiety linked to an effector moiety, wherein the compounds are capable of releasing the effector moiety on irradiation, typically by flash irradiation with UV light. These compounds are particularly suitable for focal 2-photon uncaging The photoreleasable compounds can be used to deliver effector moieties such as carboxylic acids, preferably, neuroactive amino acids to sites where their activity is required. In preferred embodiments of the invention, the caging moiety is based on 4-carboxymethoxy-5,7-dinitroinlinyl and derivatives thereof.
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Page/Page column 19-20
(2008/12/07)
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- 7-NITROINDOLINE DERIVATIVES AND THEIR USES
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7-nitroindoline compounds are disclosed that comprise a triplet sensitising group such as substituted or unsubstituted benzophenone group and can be used to cage effector species. In particular, the inclusion of a triplet sensitising group linked to the 4 or 5 position of a 7-nitroindoline derivative provides compounds which can be photolysed to release the effector species with unexpectedly enhanced photolysis efficiency. The triplet sensitising group may be linked directly to the 7-nitroindoline or via a spacer group. In some examples, the triplet sensitising group and/or the spacer group can be selected to enhance other properties of the caged compound such as its solubility, spectroscopic properties or stability (e.g. stability of the linkage between the nitroindoline moiety and the triplet sensitiser). This can help to improve the performance of the caged compound, especially in aqueous environments containing dissolved oxygen.
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- Processes for dyeing keratinous fibers with compositions which contain N-substituted 4-hydroxyindoline derivatives as couplers and oxidation bases
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The subject of the invention is a composition for the oxidation dyeing of keratinous fibers containing at least one N-substituted 4-hydroxyindoline derivative as coupler and at least one oxidation base. The invention also relates to new N-substituted 4-hydroxyindoline derivatives, to their process of synthesis, to their use as couplers for the oxidation dyeing of keratinous fibers, in combination with at least one oxidation base, and to the dyeing processes in which they are used.
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