- Immunosuppressive effects of pteridine derivatives
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This invention relates to a group of trisubstituted and tetrasubstituted pteridine derivatives, their pharmaceutically acceptable salts, N-oxides, solvates, dihydro- and tetrahydroderivatives and enantiomers, possessing unexpectedly desirable pharmaceutical properties, in particular which are highly active immunosuppressive agents, and as such are useful in the treatment in transplant rejection and/or in the treatment of certain inflammatory diseases. These compounds are also useful in preventing or treating cardiovascular disorders, allergic conditions, disorders of the central nervous system and cell proliferative disorders.
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- Inhibition of neuronal nitric oxide synthase by 4-amino pteridine derivatives: Structure-activity relationship of antagonists of (6R)-5,6,7,8- tetrahydrobiopterin cofactor
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The family of nitric oxide synthases (NOS) catalyzes the conversion of L-arginine to L-citrulline and nitric oxide (NO), an important cellular messenger molecule which has been implicated in the pathophysiology of septic shock and inflammatory and neurode
- Fr?hlich, Lothar G.,Kotsonis, Peter,Traub, Hermann,Taghavi-Moghadam, Shahriyar,Al-Masoudi, Najim,Hofmann, Heinrich,Strobel, Hartmut,Matter, Hans,Pfleiderer, Wolfgang,Schmidt, Harald H. H. W.
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p. 4108 - 4121
(2007/10/03)
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