- Sustainable organophosphorus-catalysed Staudinger reduction
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A highly efficient and sustainable catalytic Staudinger reduction for the conversion of organic azides to amines in excellent yields has been developed. The reaction displays excellent functional group tolerance to functionalities that are otherwise prone to reduction, such as sulfones, esters, amides, ketones, nitriles, alkenes, and benzyl ethers. The green nature of the reaction is exemplified by the use of PMHS, CPME, and a lack of column chromatography.
- Lenstra, Danny C.,Lenting, Peter E.,Mecinovi?, Jasmin
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supporting information
p. 4418 - 4422
(2018/10/17)
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- Structure-activity relationship studies of 4-benzyl-1H-pyrazol-3-yl β-d-glucopyranoside derivatives as potent and selective sodium glucose co-transporter 1 (SGLT1) inhibitors with therapeutic activity on postprandial hyperglycemia
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Sodium glucose co-transporter 1 (SGLT1) plays a dominant role in the absorption of glucose in the gut and is considered a promising target in the development of treatments for postprandial hyperglycemia. A series of 4-benzyl-1H-pyrazol-3-yl β-d-glucopyran
- Fushimi, Nobuhiko,Fujikura, Hideki,Shiohara, Hiroaki,Teranishi, Hirotaka,Shimizu, Kazuo,Yonekubo, Shigeru,Ohno, Kohsuke,Miyagi, Takashi,Itoh, Fumiaki,Shibazaki, Toshihide,Tomae, Masaki,Ishikawa-Takemura, Yukiko,Nakabayashi, Takeshi,Kamada, Noboru,Ozawa, Tomonaga,Isaji, Masayuki,Kobayashi, Susumu
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p. 6598 - 6612,15
(2012/12/12)
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- MATRIX METALLOPROTEINASE INHIBITORS
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This invention also relates to pharmacological compositions containing the compounds of the present invention, and methods of treating asthma, rheumatoid arthritis, COPD, rhinitis, osteoarthritis, psoriatic arthritis, psoriasis, pulmonary fibrosis, pulmonary inflammation, acute respiratory distress syndrome, perodontitis, multiple sclerosis, gingivitis, atherosclerosis, dry eye, neointimal proliferation, which leads to restenosis and ischemic heart faliure, stroke, renal diseases, tumor metastasis, and other inflammatory disorders characterized by over-expression and over-activation of matrix metalloproteinase using the compounds.
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Page/Page column 47
(2012/04/10)
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