Asymmetric Synthesis of Mellein Methyl Ether: Use of ortho-Toluate Carbanions Generated by Chiral Bases
An ortho-toluate carbanion generated from (2) by the chiral lithium amide base (6), (7), or (11) undergoes an enantioselective aldol-type reaction with acetaldehyde to give mellein methyl ether (3), in up to 53 percent enantiomeric excess.
Regan, Andrew C.,Staunton, James
p. 764 - 765
(2007/10/02)
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