- Synthesis and conformational analysis of the first 3-oxa-7-thia-1-r- azabicyclo[3.3.0]-c-5-octane single functionalised at the c-5 position
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Starting from TRIS [2-amino-2-(hydroxymethyl)propane-1,3-diol] via its thia analogue, 2-amino-2- (mercaptomethyl)propane-1,3-diol' double cyclocondensation with formaldehyde, we report a four steps synthesis of the first term in the title series of compounds, bearing the exploitable hydroxymethyl functionality at the C-5 position. Conformational analysis is discussed based on DFT calculations and 1H-DNMR.
- But, Andrada,Lameiras, Pedro,Silaghi-Dumitrescu, Loan,Batiu, Carmen,Guillard, Sophie,Ramondenc, Yvan,Darabantu, Mircea
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experimental part
p. 283 - 290
(2011/07/09)
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- Serinolic approach in the synthesis of the 3-OXA-7-THIA-1-AZABICYCLO[3.3.0] octane skeleton functionalised at the C-5 position
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We report a four steps synthesis of the first term in the title series of compounds, possessing the exploitable hydroxymethylfunctionality at the C-5 position, starting from TRIS [2-amino-2-(hydroxymethyl)propane- 1,3-diol, 2-(hydroxymethyl)ser
- But, Andrada,Batiu, Carmen,Ramondenc, Yvan,Darabantu, Mircea
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experimental part
p. 127 - 132
(2010/06/15)
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