Efficient stereoselective synthesis of the epoxyacid fragment of the azinomycins
Three concise enantioselective synthetic routes to the C17-C21 epoxyacid segment of the azinomycins are presented and were based on a Sharpless asymmetric epoxidation/kinetic resolution of racemic allylic alcohol (±)-3 that occurred with reversal of the expected sense of enantioselection.
Coleman, Robert S.,Sarko, Christopher R.,Gittinger, Jens P.