Synthesis of carbapyochelins via diastereoselective azidation of 5-(ethoxycarbonyl)methylproline derivatives
(Chemical Equation Presented) Two configurationally stable carbon-based analogues of pyochelin have been prepared from Boc-pyroglutamic acid-tert-butyl ester in 11 and 13 steps. Introduction of the amino group was achieved by a highly diastereoselective electrophilic azidation reaction to afford novel bis-α-amino acid proline derivatives.
Liyanage, Wathsala,Weerasinghe, Laksiri,Strong, Roland K.,Del Valle, Juan R.
supporting information; experimental part
p. 7420 - 7423
(2009/05/07)
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