- Efficient chemo-enzymatic synthesis of endomorphin-1 using organic solvent stable proteases to green the synthesis of the peptide
-
Endomorphin-1 (Tyr-Pro-Trp-Phe-NH2, EM-1), an effective analgesic, was efficiently synthesized by a combination of enzymatic and chemical methods. Peptide Boc-Trp-Phe-NH2 was synthesized with a high yield of 97.1% by the solvent-stab
- Sun, Honglin,He, Bingfang,Xu, Jiaxing,Wu, Bin,Ouyang, Pingkai
-
experimental part
p. 1680 - 1685
(2011/08/07)
-
- Aspartate Racemization in Synthetic Peptides. Part 2. Tendency to Racemization of Aminosuccinyl Residue
-
Aminosuccinyl (Asu) peptides, containing a strained ring system, are very vulnerable to epimerization and, during their formation, even as transients, in the presence of nucleophilic and nonnucleophilic bases, partial epimerization occurs.In the presence
- Schoen, Istvan,Szirtes, Tamas,Rill, Attila,Balogh, Gabor,Vadasz, Zsolt,et al.
-
p. 3213 - 3223
(2007/10/02)
-
- SYNTHESIS OF THE CARBOXY-TERMINAL OCTAPEPTIDE OF CHOLECYSTOKININ (CCK-8) BASED ON INCORPORATION OF O4-SULFOTYROSINE BY ENZYMATICALLY CATALYZED FORMATION OF PEPTIDE BONDS
-
Papain-catalyzed condensation of sodium salt of tert-butyloxycarbonyl-β-tert-butyloxyaspartyl-O4-sulfotyrosine (fragment 1-2) with methionyl-glycyl-tryptophyl-methionyl-aspartyl-phenylalanine amide (fragment 3-8) has been elaborated.Deprotectio
- Cerovsky, Vaclav,Hlavacek, Jan,Slaninova, Jirina,Jost, Karel
-
p. 1086 - 1093
(2007/10/02)
-
- ENZYMATIC SYNTHESIS OF ASPARTYL-CONTAINING DIPEPTIDES
-
We show that the ability of thermolysin to catalyze the coupling of aspartyl residue with other aminoacids is restricted to phenylalanine.Esterification of the two carboxylic groups of N-protected aspartic acid allows chymotrypsin and papain to catalyze the desired synthesis.
- Adisson, Laurence,Bolte, Jean,Demuynck, Colette,Mani, Jean-Claude
-
p. 2185 - 2192
(2007/10/02)
-