- Efficient Liquid-Assisted Grinding Selective Aqueous Oxidation of Sulfides Using Supported Heteropolyacid Catalysts
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The present work reports the preparation of 40MoAl200 and its full characterization using a number of analytical techniques (XRD, TEM, TGA, BET, EDX). Liquid-assisted ball milling proved to be a key tool to achieve both the best efficiency of 40MoAl200 as a novel Keggin type catalyst in the selective sulfoxidation reaction and also for succeeding in its effective recovery and reuse. In addition, the liquid assisted grinding process was studied in detail evaluating the influence of different parameters such as frequency of rotation (rpm), number and size of the stainless steel balls used and reaction time. The use of aqueous hydrogen peroxide is essential as water proved to exert a crucial role to improve both yields and selectivity towards sulfoxide formation. The procedure was representatively extended to a number of substrates with the possibility to extend the scope of the system to produce sulfoxides in high yields (up to 95 %) and satisfactory selectivities (up to 80 %). The catalyst proved to be recoverable and reusable under the optimized reaction conditions.
- Trombettoni, Valeria,Franco, Ana,Sathicq, A. Gabriel,Len, Christophe,Romanelli, Gustavo P.,Vaccaro, Luigi,Luque, Rafael
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- Triflic acid–catalyzed rearrangement of unalkylated benzene sulfonanilides
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ABSTRACT: Previous work has demonstrated that alkylated benzene sulfonanilides undergo sulfuric acid (98%)–catalyzed rearrangement to alkylamino diaryl sulfones. Similar treatment of their unalkylated analogs typically leads only to hydrolysis. Surprisingly, when the unalkylated benzene sulfonanilides react with triflic acid, rearrangement to sulfones does occur.
- Newcomer, Rebecca,McKee, James,Zanger, Murray
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p. 949 - 955
(2016/07/12)
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- Studies on 2,3,N,N'-substituted 4,4'-diaminodiphenylsulfones as potential antimalarial agents
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A series of new 4,4'-diaminodiphenylsulfones substituted at 2 and 3 position and also at primary amino group of the phenyl rings have been synthesised and evaluated for their antimalarial activity against Plasmodium berghei infection in mice. Some of these compounds were active and showed complete inhibition of parasitaemia which included 7a1-7a4, 7b3, 7b4 and 16a at 1 mg/kg i.p. for 4 days and 16a, at 0.3 mg/kg for 4 days. Some compounds tested for their synthetase inhibitory action in cell-free system isolated from P. berghei (7b1, 7b2 and 8b2) were found to be more active than diaminodiphenylsulphone. The difference in order of activity between these in vivo and in vitro tests may be due to differences in their pharmacokinetic properties.
- Saxena,Saxena,Raina,Chandra,Sen,Anand,Seydel,Wiese
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p. 1081 - 1084
(2007/10/02)
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- Experimental and Theoretical Study of Electronic Substituent Effects in 4-Aminoaryl (4-Substituted Aryl) Sulphones
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Substituent effects on the electronic structure of 23 biologically active 4-aminoaryl (4-substituted aryl) sulphones were investigated by means of 1H n.m.r., 13C n.m.r., and i.r. spectroscopy, as well as by semiempirical all-valence CNDO/2 calculations, w
- Benedetti, Pier G. De,Folli, Ugo,Iarossi, Dario,Frassineti, Chiara
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p. 1527 - 1532
(2007/10/02)
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- Process for the partial reduction of polynitrated diaryl compounds
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Polynitrated diaryl compounds of the formula given in the description are reduced with 1-2 mols of sulphides, or compounds which donate sulphide ions, per mol of nitro group in the presence of 0.5-10 mols of ammonia per mol of starting compound at 30°-110° C. to give nitroamino-diaryl compounds, for example 4,4'-dinitro-dibenzyl-2,2'-disulphonic acid is reduced to 4-nitro-4'-amino-stilbene-2,2'-disulphonic acid.
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