- Practical synthesis of regioisomeric 5(7)-amino-6,7(4,5)-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazines
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A convenient and efficient synthesis of new 5-azapurine derivatives was developed. The regioisomeric 5-amino-6,7-dihydro- and 7-amino-4,5-dihydro[1,2,4]triazolo[1,5-a][1,3,5]triazines were prepared in 3-4 steps from benzhydrazide via complementary and reg
- Dolzhenko, Anton V.,Dolzhenko, Anna V.,Chui, Wai-Keung
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- ANTI-NEOPLASTIC COMPOUNDS, COMPOSITIONS AND METHODS
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Disclosed are novel compounds which are useful as therapeutics, especially in anti-neoplastic therapy and in other therapeutic regimes where cysteine protease inhibition is implicated.
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Page/Page column 104
(2010/11/03)
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- Solvent-free synthesis of azole carboximidamides
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A one-pot procedure is described for the preparation of azole carboximidamides 2, 3 and guanidinylation of amines with 3. The X-ray crystal structure of 3b, has been determined. A one-pot procedure is described for the preparation of 1H-pyrazole-carboximidamides 2, 1H-benzotriazole-carboximidamides 3 and guanidinylation of amines with 3. The X-ray crystal structure of N,N-dimethyl-1H-benzotriazole-1-carboximidamide 3b, has been determined.
- Zahariev, Sotir,Guarnaccia, Corrado,Lamba, Doriano,?ema?ar, Ma?a,Pongor, Sándor
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p. 9423 - 9426
(2007/10/03)
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