- The synthesis of D-isoglutamine by A chemoenzymatic method
-
α-Cyclopentyl D-glutamate was obtained from dicyclopentyl D-glutamate utilizing lipase-catalyzed hydrolysis. The monoester was then treated with NH3 in methanol to produce D-isoglutamine.
- Wu, Shin-Hsiung,Chu, Fei-Ya,Chang, Chung-Ho,Wang, Kung-Tsung
-
-
Read Online
- A novel immunostimulator, N2-[α-O-Benzyl-N-(acetylmuramyl) -L-alanyl-D-isoglutaminyl]-N6-trans-(m-nitrocinnamoyl)-L-lysine, and its adjuvancy on the hepatitis B surface antigen
-
N2-[α-O-Benzyl-N-(acetylmuramyl)-L-alanyl-D-isoglutaminyl] -N6-trans-(m-nitrocinnamoyl)-L-lysine (muramyl dipeptide C, or MDP-C) has been synthesized as a novel, nonspecific immunomodulator. The present study shows that MDP-C induces
- Yang, Hong-Zhen,Xu, Song,Liao, Xue-Yan,Zhang, Suo-De,Liang, Zheng-Lun,Liu, Bai-He,Bai, Jin-Ye,Jiang, Chao,Ding, Jian,Cheng, Gui-Fang,Liu, Gang
-
p. 5112 - 5122
(2007/10/03)
-
- Solid-phase synthesis of muramyl dipeptide (MDP) derivatives using a multipin method
-
Solid-phase synthetic method of muramyl dipeptide derivatives is reported. A diverse library of muramyl dipeptides could be potentially synthesized by acylation, reductive alkylation, sulfonamide formation, urea formation, N-alkylation, amine addition, or component Ugi reactions based on this method for drug screening. (C) 2000 Elsevier Science Ltd. All rights reserved.
- Liu, Gang,Zhang, Shuo-De,Xia, Shu-Quan,Ding, Zhen-Kai
-
p. 1361 - 1363
(2007/10/03)
-
- Synthesis of a Biologically Active Fluorescent Muramyl Dipeptide Congener
-
A fluorescent-labeled muramyl dipeptide (MDP) has been prepared to probe immunoadjuvant cellular interactions.N-Acetylmuramyl-L-alanyl-D-isoglutamine (1) was synthesized in improved yield and reacted with 2-(fluoroesceinylamino)-4,6-dichloro-s-triazine (DTAF,2) to give the fluorescent adduct DTAF-MDP (3), attached through the 6-position of the sugar moiety.Adjuvant activity was assessed by using two different in vitro assays, macrophage spreading, and inhibition of macrophage migration.Both assays indicated that the apparent adjuvant activity of 3 is comparable to that of 1.
- Hiebert, C. K.,Kopp, W. C.,Richerson, H. B.,Barfknecht, C. F.
-
p. 1729 - 1732
(2007/10/02)
-