Conformationally constrained compounds which mimic the secondary structure of ?-strand regions of biologically active peptides and proteins are disclosed. Such ?-strand mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the ?-strand mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members.
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Page 73
(2008/06/13)
Beta-strand mimetics and method relating thereto
Conformationally constrained compounds which mimic the secondary structure of β-strand regions of biologically active peptides and proteins are disclosed. Such β-strand mimetic structures have utility over a wide range of fields, including use as diagnostic and therapeutic agents. Libraries containing the β-strand mimetic structures of this invention are also disclosed as well as methods for screening the same to identify biologically active members.
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(2008/06/13)
The facile production of N-methyl amino acids via oxazolidinones
A range of oxazolidinones derived from N-carbamoyl α-amino acids were prepared by an efficient method as key intermediates in the synthesis of N-methyl amino acids and peptides. The method was readily applied to most α-amino acids except those with basic side chains. The oxazolidinones were converted by reductive cleavage into N-methyl α-amino acids. CSIRO 2000.
Aurelio, Luigi,Brownlee, Robert T. C.,Hughes, Andrew B.,Sleebs, Brad E.
p. 425 - 433
(2007/10/03)
N-acyl acidic amino acid diamide derivative, a salt thereof, and an anti-ulcer agent containing the same
This invention relates to a novel N-acyl acidic amino acid diamide derivative represented by the general formula or a salt thereof: STR1 wherein each of R1, R2, R3 and R4, which may be the same or different, rep
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(2008/06/13)
Folic acid derivatives and use in radio-assay
Novel folic acid derivatives useful for radio-assaying folic acid and its metabolites in biological liquids are prepared from pteroyl-γ-glutamyl-tyrosines by iodination with I125 or I131.
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(2008/06/13)
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