- Synthesis of α-Hydroxy Ketones by Direct, Low-Temperature, in Situ Nucleophilic Acylation of Aldehydes and Ketones by Acyllithium Reagents
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The reaction of n-, sec-, and tert-butyllithium with CO at atmospheric pressure at -110 and -135 deg C in the appropriate solvent system in the presence of ketones and aldehydes generates the acyllithium, RC(O)Li, which reacts with the carbonyl compound to give the α-hydroxy ketone, generally in good yield.Reactions with aldehydes are limited in scope, working well with the t-BuLi-derived acyllithium reagents, but not with n-BuC(O)Li.
- Seyferth, Dietmar,Weinstein, Robert M.,Hui, Richard C.,Wang, Wei-Liang,Archer, Colin M.
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p. 5620 - 5629
(2007/10/02)
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- High-Yield Acyl Anion Trapping Reactions: Syntheses of α-Hydroxy Ketones and 1,2-Diketones
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The in situ generation of n-C4H9C(O)Li by the reaction of n-C4H9Li with CO at -110 deg C in the presence of ketones gives good (50-90percent) yields of α-hydroxy ketones.When the n-C4H9C(O)Li reaction is carried out in the presence of esters, good (65-80percent) yields of α-diketones are obtained, thus demonstrating that RC(O)Li can be reagents of practical utility.Similar reactions were observed with sec-C4H9Li and tert-C4H9Li.
- Seyferth, Dietmar,Weinstein, Robert M.,Wang, Wei-Liang
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p. 1144 - 1146
(2007/10/02)
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- Cp2TiCl2-catalyzed grignard reactions. 2. Reactions with ketones and aldehydes
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The reaction of Grignard reagents with ketones or aldehydes in the presence of a catalytic amount of Cp2TiCl2 leads to the corresponding reduction products in high yields. Cp2TiH intermediate was proposed to account for this observation.
- Sato, Fumie,Jinbo, Takamasa,Sato, Masao
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p. 2171 - 2174
(2007/10/02)
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