- Investigations into the structure-activity relationship in gemini QACs based on biphenyl and oxydiphenyl linker
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Eighteen novel gemini quaternary ammonium compounds were synthesized to examine the effect of linker nature, aliphatic chain length and their relative position on antibacterial and antifungal activity. The synthesized compounds showed strong bacteriostatic activity against a panel of both Gram-positive and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and two fungi. Some of these compounds exhibited a wider and more potent antimicrobial spectrum than commonly-used antiseptics, such as benzalkonium chloride (BAC), cetylpyridinium chloride (CPC), chlorhexidine digluconate (CHG) and octenidine dihydrochloride (OCT).
- Vereshchagin, Anatoly N.,Frolov, Nikita A.,Konyuhova, Valeria Yu,Kapelistaya, Ekaterina A.,Hansford, Karl A.,Egorov, Mikhail P.
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Read Online
- Aryl phenol compound as well as synthesis method and application thereof
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The invention discloses a synthesis method of an aryl phenol compound shown as a formula (3). All systems are carried out in an air or nitrogen atmosphere, and visible light is utilized to excite a photosensitizer for catalyzation. In a reaction solvent, ArNR1R2 as shown in a formula (1) and water as shown in a formula (2) are used as reaction raw materials and react under the auxiliary action of acid to obtain the aryl phenol compound as shown in a formula (3). The ArNR1R2 in the formula (1) can be primary amine and tertiary amine, can also be steroid and amino acid derivatives, and can also be drugs or derivatives of propofol, paracetamol, ibuprofen, oxaprozin, indomethacin and the like. The synthesis method has the advantages of cheap and easily available raw materials, simple reaction operation, mild reaction conditions, high reaction yield and good compatibility of substrate functional groups. The fluid reaction not only can realize amplification of basic chemicals, but also can realize amplification of fine chemicals, such as synthesis of drugs propofol and paracetamol. The invention has wide application prospect and use value.
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Paragraph 0201-0204
(2021/05/12)
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- Preparation method of 4, 4 '-dihydroxy diphenyl ether
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The invention discloses a preparation method of 4, 4 '-dihydroxy diphenyl ether. The process is as follows. The preparation method comprises the following steps: reacting 4, 4 '-dibromo diphenyl etherwith an alkaline aqueous solution, dimethyl sulfoxide, a catalytic amount of an inorganic catalyst containing copper ions and a ligand compound A to generate sodium phenolate; precipitating, separating and removing the catalyst, then introducing carbon dioxide gas to replace 4, 4 '-dihydroxy diphenyl ether, and recrystallizing the 4, 4'-dihydroxy diphenyl ether crude product by using an organic solvent to obtain a 4, 4 '-dihydroxy diphenyl ether finished product with the purity of 99% or above. The invention provides a preparation method of 2, 3, 5-tetramethylpiperidine. High purity and simple process, the preparation method is low in pollution and low in production cost; according to the method, the problems of high-temperature and high-pressure hydrolysis, high energy consumption, low safety factor, low yield and the like in the prior art are solved by applying a catalytic amount of copper ion-containing inorganic catalyst and ligand, carbon dioxide is used for acidolysis, ions limited by electronic-grade products are prevented from being introduced, and meanwhile, the method is suitable for industrial production in the aspects of cost and operation.
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Paragraph 0007; 0015-0019
(2020/06/20)
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- Industrial preparation method of 4, 4 '-dibromo diphenyl ether and 4, 4'-dihydroxy diphenyl ether
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The invention relates to an industrial preparation method of 4, 4 '-dibromo diphenyl ether and 4, 4'-dihydroxy diphenyl ether, and belongs to the technical field of organic synthesis. The method comprises the following steps: heating diphenyl ether and a catalyst in a reaction kettle to 20-100 DEG C, stirring, dropwise adding bromine, and controlling the temperature to be gradually increased alongwith the adding amount of the bromine so as to obtain a 4, 4 '-dibromo diphenyl ether crude product; absorbing hydrogen bromide gas generated in the reaction process by III grade water to prepare hydrobromic acid, wherein the reaction is carried out under a micro-negative pressure condition; recrystallizing the obtained 4, 4 '-dibromo diphenyl ether crude product by adopting an organic solvent toobtain the 4, 4'-dibromo diphenyl ether; and further adding sodium hydroxide, a catalyst and deionized water, carrying out a hydrolysis reaction, and carrying out post-treatment to prepare the 4, 4 '-dihydroxy diphenyl ether. Energy and raw material consumption can be effectively reduced, and the effects of high product efficiency, good quality and low cost are achieved. Effective environmental protection measures are taken in the production process, and a tail gas absorption device and sewage treatment facilities are arranged to effectively control and treat three wastes, so that the three wastes meet the emission standard.
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Paragraph 0059-0062
(2020/08/29)
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- Two-Dimensional Layered Zinc Silicate Nanosheets with Excellent Photocatalytic Performance for Organic Pollutant Degradation and CO2 Conversion
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Two-dimensional (2D) photocatalysts are highly attractive for their great potential in environmental remediation and energy conversion. Herein, we report a novel layered zinc silicate (LZS) photocatalyst synthesized by a liquid-phase epitaxial growth route using silica derived from vermiculite, a layered silicate clay mineral, as both the lattice-matched substrate and Si source. The epitaxial growth of LZS is limited in the 2D directions, thus generating the vermiculite-type crystal structure and ultrathin nanosheet morphology with thicknesses of 8–15 nm and a lateral size of about 200 nm. Experimental observations and DFT calculations indicated that LZS has a superior band alignment for the degradation of organic pollutants and reduction of CO2 to CO. The material exhibited efficient photocatalytic performance for 4-chlorophenol (4-CP) degradation and CO2 conversion into CO and is the first example of a claylike 2D photocatalyst with strong photooxidation and photoreduction capabilities.
- Wang, Lan,Bahnemann, Detlef W.,Bian, Liang,Dong, Guohui,Zhao, Jie,Wang, Chuanyi
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supporting information
p. 8103 - 8108
(2019/05/22)
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- Biomass-Based and Oxidant-Free Preparation of Hydroquinone from Quinic Acid
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A biomass-based route to the preparation of hydroquinone starting from the renewable starting material quinic acid is described. Amberlyst-15 in the dry form promoted the one-step formation of hydroquinone from quinic acid in toluene without any oxidants or metal catalysts in 72 % yield. Several acidic polymer-based resins and organic acids as promoters as well as a variety of reaction conditions were screened including temperature, concentration and low- and high-boiling-point solvents. A 1:4 (w/w) ratio of quinic acid/Amberlyst-15 was determined to be optimal to promote hydroquinone formation with only traces of a dimeric side-product. A mechanism has been proposed based on the decarbonylation of protonated quino-1,5-lactone that is supported by experimental and computational calculation data.
- Assoah, Benedicta,Veiros, Luis F.,Afonso, Carlos A. M.,Candeias, Nuno R.
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p. 3856 - 3861
(2016/08/16)
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- METHOD FOR PRODUCING PHENOLS
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PROBLEM TO BE SOLVED: To provide a rational and simple method which improves the yield of phenols by avoiding and suppressing the reaction of formed phenols with a diazonium salt that is an intermediate. SOLUTION: In a method for producing phenols, an aromatic amine compound is diazotized in a diluted sulfuric acid aqueous solution, then the obtained diazonium salt is supplied into a mixed aqueous solution composed of sulfuric acid and an organic compound, that is phase-separated from sulfuric acid, and the phenol formed by hydrolysis is recovered from an organic phase. COPYRIGHT: (C)2015,JPOandINPIT
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Paragraph 0016; 0018; 0019; 0021; 0023
(2018/12/12)
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- Synthesis, experimental and theoretical investigation of molecular structure, IR, Raman spectra and 1H NMR analyses of 4,4′-dihydroxydiphenyl ether and 4,4′-oxybis(1-methoxybenzene)
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4,4′-Dihydroxydiphenyl ether and 4,4′-oxybis(1-methoxybenzene) are synthesized. Experimental and theoretical studies on molecular structure, infrared spectra (IR), Raman spectra and nuclear magnetic resonance ( 1H NMR) chemical shifts of the two synthesized compounds have been worked out. All the theoretical results, which are obtained with B3LYP/6-311G(d,p) method by using the Gaussian 09 program, have been applied to simulate molecular structure, infrared, Raman and NMR spectra of the compounds. The compared results reveal that the calculated geometric parameters match well with experimental values; the scaled theoretical vibrational frequencies are in good accordance with observed spectra; and computational chemical shifts are consistent with the experimental values in most part, except for some minor deviations. These great coincidences prove that the computational method B3LYP/6-311G(d,p) can be used to predict the properties of other similar materials where it is difficult to arrive at experimental results.
- Liu, Fu,Wei, Zhongbo,Wang, Liansheng,Wang, Zunyao
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p. 285 - 294
(2013/03/28)
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- Synergy between microwave irradiation and heterogeneous catalysis in an environmentally friendly self-condensation of hydroxybenzene derivatives
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Self-condensation of 1,3,5-trihydroxybenzene and 3,5-dimethoxyphenol using solid acid catalysts and microwave irradiation produces polyhydroxy-substituted biphenyl derivatives in moderate to good yields. Condensation of 1,3,5-trihydroxybenzene with p-benzoquinone gives 2,2'-dihydroxybiphenyl derivatives in good yields. On using classical heating these reactions do not occur or afford only traces of the desired products.
- Gomez, M. Victoria,Moreno, Andres,Vazquez, Ester,De La Hoz, Antonio,Aranda, Ana I.,Diaz-Ortiz, Angel
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experimental part
p. 264 - 273
(2010/08/20)
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- MEDICAL DEVICE USING SULFONATED NEUTRALIZED POLYMERS WITH REDUCED ADHESION OF BIOLOGICAL FLUIDS
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A medical article having neutralized sulfonic acid groups on its surface, is disclosed. The article has reduced interaction with biological fluids such as insulin, human growth hormone and human serum albumin.
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- 5-Aryl thiazolidine-2,4-diones: Discovery of PPAR dual α/γ agonists as antidiabetic agents
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A novel series of 5-aryl thiazolidine-2,4-diones based dual PPARα/γ agonists was identified. A number of highly potent and orally bioavailable analogues were synthesized. Efficacy study results of some of these analogues in the db/db mice model of type 2 diabetes showed them superior to rosiglitazone in correcting hyperglycemia and hypertriglyceridemia.
- Desai, Ranjit C.,Han, Wei,Metzger, Edward J.,Bergman, Jeffrey P.,Gratale, Dominick F.,MacNaul, Karen L.,Berger, Joel P.,Doebber, Thomas W.,Leung, Kwan,Moller, David E.,Heck, James V.,Sahoo, Soumya P.
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p. 2795 - 2798
(2007/10/03)
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- Antimicrobial compositions
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The present invention relates to an enzymatic method for killing or inhibiting microbial cells or microorganisms, e.g. in laundry, on hard surfaces, in water systems, on skin, on teeth or on mucous membranes. The present invention also relates to the use of said enzymatic composition for preserving food products, cosmetics, paints, coatings, etc.
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- Polymer electrolyte and process for producing the same
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A polymer electrolyte having, in a main chain, a structural unit represented by the following formula (1):-[Ar1-(SO2-N-(X+)-SO2-Ar2)m-SO2-N-(X+)-SO2-Ar1-O]- wherein Ar1 and Ar2 independently represent a divalent aromatic groups, m represents an integer of 0 to 3, and X+ represents an ion selected from hydrogen ion, an alkali metal ion and ammonium ion, which is excellent in proton conductivity, thermal resistance and strength. The polymer electrolyte is soluble in solvents and has excellent film forming property and recycling efficiency.
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- Effects of salt, acid and base on the decomposition of 2-chlorophenol in supercritical water
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The effect of salt, acid and base as additives on the decomposition of 2-chlorophenol (2CP) in supercritical water was investigated. Four additives were selected, NaCl as a salt, HCl and H2SO4 as acids, and KOH as a base. The addition of salts and acids had a little effect on the decomposition of 2CP in supercritical water (SCW), but that of bases showed a significant effect to enhance the decomposition rate.
- Lee, Geun-Hee,Nunoura, Teppei,Matsumura, Yukihiko,Yamamoto, Kazuo
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p. 1128 - 1129
(2007/10/03)
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- Method for manufacturing bisphenol
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A method for manufacturing bisphenol by reacting phenols and ketones, characterized (1) in that an alkali metal compound and/or alkaline earth metal compound is added to bisphenol obtained by reacting a phenol and a ketone, and (2) in that the basicity of the bisphenol is adjusted so as to be equivalent to an amount of 1 × 10-8to 1 × 10-6moles of bisphenol as disodium salt with respect to 1 mole of bisphenol provides a bisphenol in which there is no residue of the organic catalysts ordinarily used in manufacturing bisphenol, so that byproducts are not produced during purification, allowing bisphenol with outstanding color tone, thermal resistance, etc., to be obtained.
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- Process for the purification of bisphenols and preparation of polycarbonates therefrom
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A phenol and a ketone are reacted to form bisphenol, and the liquid bisphenol obtained or a mixed solution of said solution and a phenol is filtered through a calcined metal filter to obtain bisphenol which makes it possible to efficiently obtain bisphenol which either does not contain fine particulate impurities or contains such impurities only in minute amounts, and a method for manufacturing polycarbonate using bisphenol obtained bythis method. The filtration grade of the calcined metal filter should be 1.0 μm or less. After filtering, the calcined metal filter can be backwashed or chemically washed and then reused. The bisphenol should preferably be bisphenol A.
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- Salicylic acid derivatives
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The heat-sensitive recording material disclosed comprises a colorless or pale colored dyestuff precursor, one or more salicylic acid derivative of the formula (1) or metal salt of the derivative and an aliphatic amide compound having 18?60 carbon atoms in molecular structure, and is excellent in thermal response and preservation stability of white portions and images. STR1 wherein X1 and X2 are a hydrogen atom, a halogen atom, an alkyl group, an alkoxy group, an aralkyl group or an aryl group, Y1 and Y2 are an oxygen atom or a sulfur atom, R1 is a hydrogen atom, an alkyl group, an aralkyl group or an aryl group, and R2 is an alkyl group, an alkenyl group, an aralkyl group or an aryl group.
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- Method for preparing aromatic bischloroformate compositions
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Bischloroformate oligomer compositions are prepared by passing phosgene into a heterogeneous aqueous-organic mixture containing at least one dihydroxyaromatic compound, with simultaneous introduction of a base at a rate to maintain a specific pH range and to produce a specific volume ratio of aqueous to organic phase. By this method, it is possible to employ a minimum amount of phosgene. The reaction may be conducted batchwise or continuously. The bischloroformate composition may be employed for the preparation of cyclic polycarbonate oligomers or linear polycarbonate, and linear polycarbonate formation may be integrated with bischloroformate composition formation in a batch or continuous process.
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- Carbonates of acetylenic alcohols
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Polymerizable carbonate compounds of the formula: wherein A is an aromatic polycycle, R1 and R2 are independently hydrogen atom or alkyl, and n is 1, 2 or 3, are disclosed. They are useful as a component of nonemanating, self-curing and heat resistant resin compositions.
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- Bischoloroformate preparation method with phosgene removal and monochloroformate conversion
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Aqueous bischloroformates are prepared by the reaction of a dihydroxyaromatic compound (e.g., bisphenol A) with phosgene in a substantially inert organic liquid (e.g., methylene chloride) and in the presence of an aqueous alkali metal or alkaline earth metal base, at a pH below about 8. After all solid dihydroxyaromatic compound has been consumed, the pH is raised to a higher value in the range of about 7-12, preferably 9-11, and maintained in said range until a major proportion of the unreacted phosgene has been hydrolyzed. At the same time, any monochloroformate in the product may be converted to bischloroformate.
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- Cyclic monocarbonate bishaloformates
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Cyclic monocarbonate bischloroformates are prepared by the reaction of a carbonyl halide such as phosgene with a bridged substituted resorcinol or hydroquinone such as bis(2,4-dihydroxy-3-methylphenyl)methane or bis(2,5-dihydroxy-3,4,6-trimethylphenyl)methane in the presence of aqueous alkali metal hydroxide. The cyclic monocarbonate bischloroformates may be used for the preparation of linear or cyclic polycarbonates containing cyclic carbonate structural units, which may in turn be converted to crosslinked polycarbonates.
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- Polyetherimide bisphenol compositions
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Polyetherimide bisphenols and bischloroformates are prepared by the reaction of dianhydrides or certain bisimides with aminophenols or mixtures thereof with diamines. They are useful as intermediates for the preparation of cyclic heterocarbonates, which may in turn be converted to linear copolycarbonates. The bisphenols can also be converted to salts which react with cyclic polycarbonate oligomers to form block copolyetherimidecarbonates.
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- Method for making 4,4'-dihydroxydiphenyl ether
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A method for making 4,4'-dihydroxydiphenyl ether from diphenyl ether by oxidatively iodinating diphenyl ether to 4,4'-diiododiphenyl ether and/or 4-hydroxy-4'-iododiphenyl ether, hydrolyzing this product with a base, recovering iodine from the solution containing iodide, and recycling the iodine to the iodination step.
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- Bisfluoran chromogenic compounds, preparation thereof, and pressure-sensitive copy systems employing same
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A substantially colorless bisfluoran chromogenic material having the structural formula STR1 wherein R1 and R2 each represent an alkyl group; X and Y each represent a hydrogen atom, a halogen atom, an hydroxyl group, an alkyl group, a nitro group, an amino group, an acyl group, or a carboalkoxy group; Z represents an oxy radical, a carbonyl group, an alkylene group, an alkylidene group, a sulfonyl group, or a thio radical; and n represents an integer from 0 to 1. The bisfluoran compounds are produced by reacting a 4-dialkylamino-2-hydroxy-2'-carboxybenzophenone with a diphenol wherein the diphenol is unsubstituted in at least one of the positions ortho to an hydroxyl group in each of the phenyl rings. The bisfluorans are used in pressure-sensitive copy systems comprising a support bearing microcapsules containing the bisfluorans, alone, or in combination with other color-forming materials.
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