Oxidative Coupling of Phenols and Phenolic Ethers. Part 4. Synthesis of Dibenzazonines and a Dibenzazecine, via Direct Coupling
Two series of amides, N-phenethylphenylacetamides (9) and the bisphenetylamides (11), including diphenolic monophenolic, and non-phenolic types, were treated with a range of one-electron oxidants.With the tetramethoxy-derivative (11e) intramolecular coupling yielded a dibenzazonine (16) in 36percent yield.Similar oxidation of the homologue (18) gave a dibenzazecine (19) in 60percent yield.
McDonald, Edward,Wylie, Robert D.
p. 1104 - 1108
(2007/10/02)
Method for increasing cardiac contractility
N-Mono or dihydroxyphenylalkyl dopamine derivatives and salts thereof are inotropic agents useful in a method for treatment of acutely depressed cardiac insufficiency.
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(2008/06/13)
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