- Synthesis and herbicidal activity of phenylpyridines - A new lead
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Novel phenylpyridines were synthesized based on molecular modeling oriented design by super-position of herbicidal phenyl-uracils, -indazoles, and diphenylethers. Their preparation follows Suzuki-type coupling conditions of reactive 2-chloro-pyridines with appropriate 2,5-substituted 4-chloro-phenyl boronic acids. Depending on the nature of substituents in the pyridine, and in particular the phenyl group, a large number of derivatives are readily accessible. Besides open-chain phenylpyridines also anellated compounds, such as pyridine-substituted 2H-1,4-benzothiazin-3(4H)-one or 3,4-dihydro-1H- quinolin-2-one, were prepared. Phenylpyridines act by inhibition of protoporphyrinogen-IX-oxidase. Their synthesis will be described in conjunction with structure-activity relationships. Phenylpyridines are highly active against many important broadleaf and grass weed species under pre- and - in particular - post-emergent conditions.
- Schaefer, Peter,Hamprecht, Gerhard,Puhl, Michael,Westphalen, Karl-Otto,Zagar, Cyrill
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p. 715 - 719
(2007/10/03)
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- Process and intermediate products for preparing pyridyl-4-fluoroanilines
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PCT No. PCT/EP97/01336 Sec. 371 Date Sep. 14, 1998 Sec. 102(e) Date Sep. 14, 1998 PCT Filed Mar. 17, 1997 PCT Pub. No. WO97/34872 PCT Pub. Date Sep. 25, 1997A process for preparing pyridyl-substituted N-phenylhydroxylamines by catalytic hydrogenation of t
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