- Synthesis of diisothiocyanato-functionalized 2,2-bipyridines
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Three new diisothiocyanato-functionalized 2,2-bipyridines have been synthesized in four consecutive steps. Starting from 4-amino-2-chloro- and 2-amino-6-bromopyridine, respectively, we first prepared the corresponding diamino-2,2-bipyridines via homo- or Negishi cross-coupling reactions which were subsequently reacted with thiophosgene.
- Kremer, Christopher,Luetzen, Arne
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- INHIBITING THE TRANSIENT RECEPTOR POTENTIAL A1 ION CHANNEL
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The present invention relates to pharmaceutical compounds of the Formula (I), or a pharmaceutically acceptable salt or composition thereof, and methods of their use for the treatment of pain, respiratory conditions, as well as inhibiting the Transient Receptor Potential Al ion channel (TRPA1).
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Page/Page column 144; 145
(2016/04/09)
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- Towards allosteric receptors synthesis of β-cyclodextrin- functionalised 2,2'-bipyridines and their metal complexes
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Herein, we present three new 2,2'-bipyridines that carry two β-cyclodextrin moieties in different substitution patterns. When coordinated by zinc(II) or copper(I) ions (or their complexes), these compounds undergo conformational changes and switch between
- Kremer, Christopher,Schnakenburg, Gregor,Lutzen, Arne
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p. 814 - 824
(2014/05/06)
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- Pyrimidine Derivatives Which Are Antagonists Of Vitronectin Receptor
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A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
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Page/Page column 15
(2010/11/30)
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- Synthesis of substituted 2,2′-bipyridines from 2-bromo- or 2-chloropyridines using tetrakis(triphenylphosphine)palladium(0) as a catalyst in a modified Negishi cross-coupling reaction
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A protocol for an efficient, modified Negishi cross-coupling strategy for substituted 2,2′-bipyridines employing tetrakis(triphenylphosphine) palladium(0) as a simple, commercially available, and relatively inexpensive catalyst for both 2-bromo- and 2-chl
- Kiehne,Bunzen,Staats,Luetzen
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p. 1061 - 1069
(2008/02/02)
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- Novel vitronectin receptor antagonist derivatives, method for preparing same, use thereof as medicines and pharmaceutical compositions containing same
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A subject of the invention is the compounds of formula (I): in which R1, R2, R3, R4 and G have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
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Page/Page column 62-63
(2008/06/13)
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- Multicyclic aromatic compounds and uses thereof
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Multicyclic aromatic compounds useful as complexing agents having the general formula: Methods of complexing and quantitating a component in a sample such as urea or guanidine are also disclosed.
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- 2-AMINO-6-(2-SUBSTITUTED-4-PHENOXY)-SUBSTITUTED-PYRIDINES
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This present invention relates to compounds of the formula wherein G, R1 and R2 are defined as in the specification, to pharmaceutical compositions containing them and to their use in the treatment and prevention of central nervous system and other disorders.
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- 6-phenyl-pyridin-2-ylamine derivatives
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The present invention relates to certain 6-phenyl-pyridin-2-ylamine derivatives that exhibit activity as nitric oxide synthase (NOS) inhibitors, to pharmaceutical compositions containing them and to their use in the treatment and prevention of central nervous system disorders.
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- A new class of selective and potent inhibitors of neuronal nitric oxide synthase
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The synthesis and SAR of a series of 6-(4-(substituted)phenyl)-2-aminopyridines as inhibitors of nitric oxide synthase are described. Compound 3a from this series shows potent and selective inhibition of the human nNOS isoform, with pharmacokinetics sufficient to provide in vivo inhibition of nNOS activity.
- Lowe III, John A.,Qian, Weimin,Volkmann, Robert A.,Heck, Steven,Nowakowski, Jolanta,Nelson, Robert,Nolan, Charles,Liston, Dane,Ward, Karen,Zorn, Stevin,Johnson, Celeste,Vanase, Michelle,Faraci, W. Stephen,Verdries, Kimberly A.,Baxter, James,Doran, Shawn,Sanders, Martin,Ashton, Mike,Whittle, Peter,Stefaniak, Mark
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p. 2569 - 2572
(2007/10/03)
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