A new strategy, utilizing IR and mass spectrometry, has been developed to design appropriate reagents and reaction conditions for enantioselective enzymatic protection of amines with readily removable protecting groups.
Enzymatic resolution of (±)-trans-2-aminocyclohexanol and (±) trans-2-aminocyclopentanol
Candida antarctica lipase (CAL) catalyzes the resolution of (±)-trans-2-aminocyclohexanol by alkoxycarbonylation or acylation reactions. Besides, N-benzyloxycarbonyl derivatives of (±)-trans-2-aminocyclohexanol and (±)-trans-2-aminocyclopentanol are efficiently resolved through O-acylation by Pseudomonas cepacia lipase (PSL).
Maestro, Alicia,Astorga, Covadonga,Gotor, Vicente
p. 3153 - 3159
(2007/10/03)
A General Method for the Separation of Enantiomeric trans-2-Substituted Cyclohexanols
An number of different racemic, trans-2-substituted cyclohexanols has been prepared in high optical purity by optical resolution of the respective 2'-substituted cyclohexyl butanoates with the aid of commercially available lipases.
Hoenig, Helmut,Seufer-Wasserthal, Peter
p. 1137 - 1140
(2007/10/02)
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