- Asymmetric synthesis of O-methylneferine
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Diastereoselective Pictet-Spengler reaction of 2-arylethylamine bearing an N-(R)-1-(1-naphthyl)ethylcarbamoyl group with arylacetaldehyde gave 1-benzyltetrahydroisoquinoline in good yield with moderate diastereoselectivity. The reaction was applied to asymmetric synthesis of O-methyl derivative of neferine, an alkaloid of the lotus embryo, Nelumbo nucifera Gaertner.
- Nishimura, Katsumi,Horii, Shinji,Tanahashi, Takao
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p. 865 - 876
(2019/04/26)
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- Synthesis and pharmacological activity of alkaloids from embryo of lotus, Nelumbo nucifera
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Bisbenzylisoquinoline alkaloid, nelumboferine which was recently isolated from the embryo of Nelumbo nucifera, and stereoisomers of neferine, which is a major alkaloid of the embryo of N. nucifera, were stereoselectively synthesized. Pharmacological activity of nelumboferine, stereoisomers of neferine, liensinine, isoliensinine, and O-methylneferine were evaluated.
- Nishimura, Katsumi,Horii, Shinji,Tanahashi, Takao,Sugimoto, Yumi,Yamada, Jun
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