- FUROISOQUINOLINE DERIVATIVES, PROCESS FOR PRODUCING THE SAME AND USE THEREOF
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A compound having a partial structure represented by Formula: or a salt thereof has an excellent phosphodiesterase (PDE) IV-inhibiting effect, and is useful as a prophylactic or therapeutic agent against inflammatory diseases, for example, bronchial asthma, chronic obstructive pulmonary disease (COPD), rheumatoid arthritis, autoimmune disease, diabetes and the like.
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- Crystal Engineering and Substituent Effect of Hindered Phenols for SHG Materials
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2,6-di-tert-butylphenol moiety was found to be effective to control molecular packing in crystals for SHG materials.Many derivatives having compact acceptor group at 4-position of hindered phenols showed SHG responses depending on the electron withdrawing effect of an acceptor.The X-ray structural analyses revealed that molecular packing was controlled both by the steric requirements and the intermolecular hydrogen bonding.
- Takagi, Koichi,Mizuno, Akira,Kubata, Michiru,Mizoguchi, Akira,Furushow, Masaru,Matsuoka, Masaru
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p. 1743 - 1746
(2007/10/02)
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- OXIDATION OF 3,5-DI-tert-BUTYL-4-HYDROXYBENZYL ALCOHOL AND 3,5-DI-tert-BUTYL-4-HYDROXYBENZALALDEHYDE BY OXYGEN IN AQUEOUS AMMONIUM SOLUTION
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The main reaction products during the oxidation of 3,5-di-tert-butyl-4-hydroxy-benzyl alcohol and 3,5-di-tert-butyl-4-hydroxybenzaldehyde by oxygen in a waterpropanol solution of ammonia are 3,3',5,5'-tetra-tert-butyldiphenoquinone, 2,6-di-tert-butyl-1,4-benzoquinone, and 3,3'5,5'-tetra-tert-butylindophenol, which is formed in the reaction of the above-mentioned p-benzoquinone with ammonia.Three nitrogen containing substances were also found in the products from the oxidative ammonolysis of the aldehyde, i.e., 2,6-di-tert-butyl-4-cyanophenol, 2,6-di-tert-butyl-4--2,5-cyclohexadien-1-one, and a third compound with a molecular mass of 490, for which the elemental composition was determined.
- Fedulina, T. G.,Deineko, I. P.,Klindukhov, V. P.
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p. 1540 - 1548
(2007/10/02)
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- OXIDATION OF 2,6-DI-tert-BUTYL-4-METHYLPHENOL BY OXYGEN IN AQUEOUS AMMONIA SOLUTION
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Both monomeric and dimeric oxidation products are formed during the oxidation of 2,6-di-tert-butyl-4-methylphenol (ionole) by oxygen in a water-propanol solution of ammonia.Two nitrogen-containing compounds 3,3'-5,5'-tetra-tert-butylindophenol and 2,6-di-tert-butyl-4-cyanophenol are also formed, and their amounts in the reaction mixture increase with increase in temperature (45-120 deg C).
- Fedulina, T. G.,Deineko, I. P.,Zenkevich, I. G.,Zarubin, M. Ya.
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p. 1373 - 1377
(2007/10/02)
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- Sulphur Nitrides in Organic Chemistry. Part 16. The Reaction of Tetrasulphur Tetranitride with Alkyl- and Alkylhalophenols. Preparation of 2,1,3-Benzothiadiazoles.
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The reaction of tetrasulphur tetranitride (N4S4) with alkylphenols 1a-o and alkylhalophenols 2a-i gave the corresponding 2,1,3-benzothiadiazoles 3a-n in 12-84percent yields.The reaction with 2,6-di-t-butylphenols 1p, q and 2j afforded N,N'-thiobis(1,4-ben
- Mataka, Shuntaro,Takahashi, Kazufumi,Shiwaku, Sohgo,Tashiro, Masashi
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p. 3649 - 3665
(2007/10/02)
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- REACTION OF SUPEROXO Co(III) COMPLEX WITH STABLE PHENOXY RADICALS
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A typical superoxo complex +=PPh3>3 combines with stable phenoxy radicals in CH2Cl2 leading to selective formation of peroxy-p-quinols except for 2,4,6-tri-t-butylphenoxy radical, representing radical reactivity of the complex
- Nishinaga, A.,Tomita, H.,Matsuura, T.
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p. 3407 - 3408
(2007/10/02)
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