- An efficient synthesis of 6-substituted 2-(2H-[1,2,4]triazol-3- ylmethyl)-1,2,3,4-tetrahydro-isoquinolines
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A synthesis of 6-nitro and 6-amino 2-(2H-[1,2,4]triazol-3- ylmethyl)1,2,3,4-tetrahydro-isoquinolines using a bis-alkylation process is described. 5-(Aminomethyl)-1-(p-methoxybenzyl)-triazole was prepared by a regioselective route from 1,2,4-triazole.
- Urban, Frank J.,Breitenbach, Ralph
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p. 645 - 653
(2007/10/03)
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- Process and intermediates for preparing 4'-trifluoromethylbiphenyl-2-carboxylic acid [2-(2H-[1,2,4]triazol-3-ylmethyl)-1,2,3,4-tetrahydro-isoquinolin-6-yl]-a mide
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A process for preparing the compound of formula (1) is disclosed. STR1 The starting materials are an N-triazolylmethyl-6-aminoisoquinoline and a 4-biphenyl-2-carboxylic acid derivative.
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