SYNTHESIS OF QUINOLINE 5-CARBOXAMIDES USEFUL FOR THE PREPARATION OF PDE IV INHIBITORS
In one embodiment, the present application discloses a process for making the compound of the formula:
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Page/Page column 22
(2010/02/11)
8-Methoxyquinolines as PDE4 inhibitors.
The synthesis and pharmacological profile of a novel series of 2-substituted 8-methoxyquinolines is described. The 2-trifluoromethyl compound was found to be a potent inhibitor of phosphodiesterase type 4 (PDE4).
Billah, Motasim,Buckley, George M,Cooper, Nicola,Dyke, Hazel J,Egan, Robert,Ganguly, Ashit,Gowers, Lewis,Haughan, Alan F,Kendall, Hannah J,Lowe, Christopher,Minnicozzi, Michael,Montana, John G,Oxford, Janet,Peake, Joanna C,Picken, C Louise,Piwinski, John J,Naylor, Robert,Sabin, Verity,Shih, Neng-Yang,Warneck, Julie B H
p. 1617 - 1619
(2007/10/03)
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