In vitro oxidative metabolism of 6-mercaptopurine in human liver: Insights into the role of the molybdoflavoenzymes aldehyde oxidase, xanthine oxidase, and xanthine dehydrogenase
Anticancer agent 6-mercaptopurine (6MP) has been in use since 1953 for the treatment of childhood acute lymphoblastic leukemia (ALL) and inflammatory bowel disease. Despite being available for 60 years, several aspects of 6MP drug metabolism and pharmacok
Choughule, Kanika V.,Barnaba, Carlo,Joswig-Jones, Carolyn A.,Jones, Jeffrey P.