- Synthesis of artificial glycoconjugates of arginine-vasopressin and their antidiuretic activities
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Arginine-vasopressin (AVP) derivatives modified at the glutamine side chain amide with carbohydrate via an alkylene spacer (1a-d) were synthesized from new glycosylated glutamine derivatives (3a-d) by solid-phase synthesis. Glycoconjugates of AVP modified
- Susaki,Suzuki,Ikeda,Yamada,Watanabe
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- USES OF ANTI-CD3 ANTIBODY FOLATE BIOCONJUGATES
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Described herein are anti-CD3 antibody folate bioconjugates and uses thereof in the treatment of diseases, conditions, and cancers.
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Paragraph 00347; 00350
(2021/09/03)
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- ANTI-CD3 ANTIBODY FOLATE BIOCONJUGATES AND THEIR USES
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Described herein are novel anti-CD3 Folate antibodies and uses thereof in the treatment of diseases or conditions that would benefit from such.
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Paragraph 00338; 00339; 00342
(2020/03/23)
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- Preparation method of N-fluorenylmethoxycarbonyl-gamma-(S-triphenylmethyl-cysteamine)-L-glutamic acid
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The invention provides a preparation method of N-fluorenylmethoxycarbonyl-gamma-(S-triphenylmethyl-cysteamine)-L-glutamic acid. The preparation method mainly solves the technical problems of complexity, long period, high cost, and low yield of an original process, and comprises the following steps: (1) preparing N-fluorenylmethoxycarbonyl-L-glutamic acid; (2) preparing N-fluorenylmethoxycarbonyl-L-glutamic acid-1-benzyl ester; (3) preparing S-triphenylmethyl cysteamine; (4) preparing N-fluorenylmethoxycarbonyl-gamma-(S-triphenylmethyl-cysteamine)-L-glutamic acid-alpha-benzyl ester; and (5) preparing N-fluorenylmethoxycarbonyl-gamma-(S-triphenylmethyl-cysteamine)-L-glutamic acid. The method is rapid, high in yield and simple in separation and purification, and the used solvent is environment-friendly and is suitable for mass production.
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Paragraph 0067
(2020/10/05)
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- Novel trivalent anti-influenza reagent
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We designed and synthesized novel trivalent anti-influenza reagents. Sialyllactose was located at the terminal of each valence which aimed to block each receptor-binding site of the hemagglutinin (HA) trimer on the surface of the virus. Structural analyse
- Feng, Fei,Miura, Nobuaki,Isoda, Norikazu,Sakoda, Yoshihiro,Okamatsu, Masatoshi,Kida, Hiroshi,Nishimura, Shin-Ichiro
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supporting information; experimental part
p. 3772 - 3776
(2010/09/03)
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- FOLATE-CONJUGATES AND CORRESPONDING METAL-CHELATE COMPLEXES FOR USE IN DIAGNOSTIC IMAGING AND RADIOTHERAPY
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The present invention is directed towards novel folate-conjugates of formula I wherein F is a folate or derivative thereof, Z1, Z2, Z3 are independently of each other C or N, S1 to S4 are independentl
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Page/Page column 58
(2008/12/08)
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